@justy can you say which SSRI?
Citalopram
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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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@justy can you say which SSRI?
I had a really bad time with Citalopram, cuased my OI, messed up my sleep and generally caused havocCitalopram
I wish I knew what it was that made M.E patients more prone to problems with SSRI's. I know Dr Myhill has mentioned this, but is there actually any research to back this up - I know a lot of us report problems, but that's anecdotal...
Collectively, the results of the studies reviewed suggest that the IL-1 and 5-HT systems engage in reciprocal interactions that contribute to the regulation of NREM sleep. In the POA/BF IL-1 enhances axonal 5-HT release and 5-HT stimulates the synthesis of IL-1, which inhibits wake-promoting neurons. IL-1 also inhibits wake-active serotonergic cell bodies in the DRN. Thus, IL-1 exerts opposite effects on serotonergic cell bodies and axon terminals. These effects complement each other and they both contribute to the same functional outcome: the enhancement of NREM sleep.
@Martial I just remembered you said to take niacin when feeling bad. . I thought I read that niacin stops the methylation process.
Did I read it wrong? Where am I confused?
yes, neurological. Many of us CFS patients get defensive when called depressive, including myself because we think it's a purely psychological issue and whe have a physical problem.Can so relate to the "fried brain". Neurologically fried ?
I on the other hand suffer no depression whatsoever unless I am on the receiving end of problems created by the ignorance of others.yes, neurological. Many of us CFS patients get defensive when called depressive, including myself because we think it's a purely psychological issue and whe have a physical problem.
But now I know for sure that most if not all psychological issues have underlying physical abnormalities so a depressed patient can have CFS and the other way around too. Depression is infact a serotonin deficiency, which then leads to behavioural abnormalities, but at the core its a physical thing.
I too have serotonin deficiency and since I was at a CFS clinic, the professor and leader of the clinic told me, that most CFS patients have a neurotransmitter abnormality. You can also read my signature link on that subject. I think that's a major aspect for us to look into