Of course, patients who are exposed to both mold and viruses may have a combination of CIRS and ME/CFS, so perhaps it may not always be a clearcut case of whether you have either CIRS or ME/CFS; you may have a bit of both.
I agree with this and in my case, I had severe mono from EBV (March/April 2012) about seven months prior to moving into rental with toxic mold (Nov 2012). I think b/c my immune system was not fully recovered from the EBV (which I was IgM positive for several years post mono), that I was more susceptible to the mold vs. a healthy person.
So Shoemaker says that in these genetically susceptible patients, mycotoxins and other biotoxins are not detoxified. The genetic susceptibility Shoemaker refers to relates your HLA DR genotype: Shoemaker say that 24% of the population have the genotype that makes them unable to properly detoxify mycotoxins and biotoxins. Shoemaker's treatment is to use cholestyramine, which binds to the mycotoxins in the intestines, and pulls them out of the body.
I did the HLA DR test and had what Shoemaker calls the most "Dreaded Haplotype" which cannot detox mold. He was not my doctor and my mold doc had very mixed feelings re: Shoemaker and created her own protocols which were tailored to each patient. What was interesting, and I did not understand it until the doctor explained it to me, is that (at that time), I tested negative in a urine sample for mycotoxins (from Brewer's lab) even though I was very sick and tested positive on blood work. My husband and step-daughter tested positive on the urine test (but were not sick like me although they were affected by the mold with headaches, sinus issues, etc). My mold doc said this was b/c my body could not detox the mold so it was not excreted by my urine vs. my family could detox it so it showed up in the urine test. She said we could re-test after I did nebulized glutathione and binders but I never did.
I was not able to try CSM (cholestyramine) at that time b/c my MCAS was so severe and my mold doctor felt it was too dangerous for me. I tried activated charcoal, bentonite clay, but could not tolerate micro dose (at that time) b/c of my MCAS. I ended up using Nebulized Glutathione (which was very helpful) and very gentle binders like oats and apple pectin. I did this for about 9-10 months approx.
Do mycotoxins contain antigenic regions that the immune system would recognize and produce antibodies against?
@halcyon Does this mean that if someone has antibodies attacking the mycotoxins and the toxins finally went away but the antibodies mistakenly kept attacking, that they could turn into autoantibodies? I still cannot figure out how I ended up with eleven autoantibodies when everything for me started off viral and mold.