SWAlexander
Senior Member
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Highlight
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SARS-CoV-2, the cause of the pandemic coronavirus disease, causes dysregulation of an immune response.
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Infection of respiratory epithelium by virus triggers both innate and acquired immunity that led to the immune system's hyperactivation.
•
Therefore, triggering chronic inflammation can contribute to autoimmune disease.
•
Post-Covid-19 autoimmunity may be due to molecular mimicry, bystander activation of T cells, transient immunosuppression, and pro-inflammatory cytokines, which might complicate SARS-CoV-2 vaccination.
Abstract
Autoimmunity, hyperstimulation of the immune system, can be caused by a variety of reasons. Viruses are thought to be important environmental elements that contribute to the development of autoimmune antibodies. It seems that viruses cause autoimmunity with mechanisms such as molecular mimicry, bystander activation of T cells, transient immunosuppression, and inflammation, which has also been seen in post-Covid-19 autoimmunity. Infection of respiratory epithelium by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dysregulates the immune response, triggers both innate and acquired immunity that led to the immune system's hyperactivation, excessive cytokine secretion known as “cytokine storm,” and finally acute respiratory distress syndrome (ARDS) associated with high mortality. Any factor in the body that triggers chronic inflammation can contribute to autoimmune disease, which has been documented during the Covid-19 pandemic. It has been observed that some patients produce autoantibody and autoreactive CD4+ and CD8+ T cells, leading to the loss of self-tolerance. However, there is a scarcity of evidence defining the precise molecular interaction between the virus and the immune system to elicit autoreactivity. Here, we present a review of the relevant immunological findings in Covid-19 and the current reports of autoimmune disease associated with the disease.
https://www.sciencedirect.com/science/article/pii/S1043466622000825?via=ihub
Today I´m convinced that existing immunodeficiency, is the foundation for ME/CFS and is emphasized by either bacteria or viruses.
Highlight
•
SARS-CoV-2, the cause of the pandemic coronavirus disease, causes dysregulation of an immune response.
•
Infection of respiratory epithelium by virus triggers both innate and acquired immunity that led to the immune system's hyperactivation.
•
Therefore, triggering chronic inflammation can contribute to autoimmune disease.
•
Post-Covid-19 autoimmunity may be due to molecular mimicry, bystander activation of T cells, transient immunosuppression, and pro-inflammatory cytokines, which might complicate SARS-CoV-2 vaccination.
Abstract
Autoimmunity, hyperstimulation of the immune system, can be caused by a variety of reasons. Viruses are thought to be important environmental elements that contribute to the development of autoimmune antibodies. It seems that viruses cause autoimmunity with mechanisms such as molecular mimicry, bystander activation of T cells, transient immunosuppression, and inflammation, which has also been seen in post-Covid-19 autoimmunity. Infection of respiratory epithelium by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dysregulates the immune response, triggers both innate and acquired immunity that led to the immune system's hyperactivation, excessive cytokine secretion known as “cytokine storm,” and finally acute respiratory distress syndrome (ARDS) associated with high mortality. Any factor in the body that triggers chronic inflammation can contribute to autoimmune disease, which has been documented during the Covid-19 pandemic. It has been observed that some patients produce autoantibody and autoreactive CD4+ and CD8+ T cells, leading to the loss of self-tolerance. However, there is a scarcity of evidence defining the precise molecular interaction between the virus and the immune system to elicit autoreactivity. Here, we present a review of the relevant immunological findings in Covid-19 and the current reports of autoimmune disease associated with the disease.
https://www.sciencedirect.com/science/article/pii/S1043466622000825?via=ihub
Today I´m convinced that existing immunodeficiency, is the foundation for ME/CFS and is emphasized by either bacteria or viruses.