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Salidroside (from the herb Rhodiola rosea) is as effective against coxsackievirus B as the antiviral ribavirin


Senior Member
Salidroside is one of the active principles of Rhodiola rosea, a herb which is used for anxiety, fatigue and depression.

An in vivo study on mice found that salidroside doses of 20, 40 and 80 mg/kg improved survival rate in mice infected with coxsackievirus B3, and performed better than the enterovirus antiviral ribavirin.

A mouse 20 mg/kg dose is equivalent to a human dose of 1.63 mg/kg, which for an 80 kg person is an oral dose of 130 mg of salidroside.

250 grams of Rhodiola rosea extract containing 3% salidroside can be bought in the US for $22 here, and in the UK for £19 here.

And this supplement contains 6% salidroside.

To achieve a dose of 130 mg of salidroside, one would need to take around 4.3 grams of this 3% Rhodiola rosea extract. Whether this high dose of Rhodiola rosea can be safely taken, I am not sure. This article says studies on Rhodiola rosea have used doses up to 1500 mg daily.

As to the antiviral mechanism of salidroside, the study says:
Salidroside significantly increased mRNA expression of IL-10 and IFN-gamma, but decreased TNF-a and IL-2 mRNA expression, suggesting that salidroside may prevent inflammatory responses and strengthen host resistance against virus infection by enhancing the expression of IL-10 and IFN-gamma.

So it would appear that salidroside works by boosting interferon gamma and IL-10.

Although it's not so clear that IL-10 will help fight a persistent coxsackievirus B infection, since IL-10 is an anti-inflammatory cytokine.

According to Wikipedia, salidroside has antidepressant, anti-anxiety, antioxidant, anti-inflammatory and neuroprotective effects.
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