Hi, Pete.
I'd say that you have already gotten some good interpretation of your test results. There is a gut dysbiosis problem, and I agree that that needs to be addressed first. Your comprehensive stool analysis did not include antimicrobial sensitivity testing, so it's difficult to say which antimicrobials would be most helpful for knocking down the populations of the unfriendly bacteria. It's possible that you could overwhelm them using probiotics, but I think it's often true that the unhelpful bacteria must be knocked down first, before the friendly ones can be built up.
Will do, antibiotics is not an option here???
I think that the reason you have IgG antibodies to several foods is that the gut dysbiosis has resulted in intestinal permeability ("leaky gut" syndrome), so if you can correct the dysbiosis, I think the food sensitivities will resolve. In the meantime, it is best not to eat the ones that you are sensitive to, and also to rotate your foods to avoid other sensitivities.
This is def my theory as well, all these foods were eaten at the time of the testing accept for the paranuts.Im following the Paul chek food rotation at the moment.
Your carbohydrate metabolism is not operating very well, judging by pyruvate being below the detection limit. This could be caused by a low-carb diet, poor absorption of carbs by the gut, or low magnesium.
I have been trying to go as low on carbs as possible to batle the gut problems.
Normally, when carbs are not being supplied to the citric acid cycle at a normal rate, fatty acids are mobilized and the cells go into ketosis. However, in your case, this is not happening, based on beta hydroxybutyrate being below the detection limit. You have some omega oxidation of fatty acids going on, but not much. The fat stains on the stool test suggest that you may not be digesting or absorbing fats very well, perhaps because of the dysbiosis or because of bile insufficiency. It's not possible to say for sure what the cause is with the available data. You could also be low in carnitine or B2 or both.
The first three citric acid cycle metabolites are low because not much in the way of carbs or fats are being fed to the cycle.
Alpha ketoglutarate is below the detection limit. This is probably due to low B3, magnesium or manganese, as well as low B6 and/or B2. Succinate is normal, suggesting that you are feeding some branched-chain amino acid into the citric acid cycle. Fumarate is below the detection limit, perhaps due to B2 deficiency.
Correct, I have been using EAA
The high xanthurenate and kynurenate indicate low B6 or B2 or both. The high beta-hydroxyvalerate indicates a biotin deficiency.
The high formiminoglutamate indicates low folate. Although methylmalonate is not high, I suspect that you have a functional B12 deficiency, based on the high formiminoglutamate and the low pyroglutamate (which indicates glutathione depletion). The methylmalonate marker can be masked by B-vitamin deficiencies.
Your neurotransmitter metabolites are off-normal. It's difficult to be specific about them, but they are affected by B-vitamins, and you do have deficiencies in at least some of them.
The high 8-hydroxy-2-dexyguanosine indicates oxidative stress that is damaging the DNA. This would be consistent with glutathione depletion.
I have been taking these supps, very expensive, anything you have heard of or is it just bogus??? http://www.lyposphericnutrients.co.uk/default.aspx
Your detox system is working hard to try to take out toxins, but general disruption of the sulfur metabolism is hindering this. There is very low flow in the transsulfuration pathway, based on alpha-hydroxybutyrate being below the detection limit. Low B2 and/or B6 could be responsible.
I suspect that your urea cycle is not operating very well, based on both fumarate and orotate being below the detection limit. If we had an amino acids panel, I could say more about that.
Your cortisol and DHEA look pretty good.
So generally speaking, I agree with what others have said. The gut issues need to be dealt with first. Then the deficiencies need to be corrected, particularly B-complex vitamins and essential minerals, but it would probably be a good idea to take a good multivitamin-multimineral to cover all the essential ones. You will need to consume some good quality protein to supply the necessary amino acids, and some fish oil to supply essential fatty acids to repair your cell membranes, which will have been damaged by the oxidative stress.
If your methylation cycle and glutathione do not bounce back after these things are corrected, then I think you will need a methylation protocol that includes methylfolate and high-dose hydroxo or methyl B12, either sublingually or by injection.
I recommend that you work with a physician for treatment.
Best regards,
Rich