***Hi, Pete.
I'd say that you have already gotten some good interpretation of your test results. There is a gut dysbiosis problem, and I agree that that needs to be addressed first. Your comprehensive stool analysis did not include antimicrobial sensitivity testing, so it's difficult to say which antimicrobials would be most helpful for knocking down the populations of the unfriendly bacteria. It's possible that you could overwhelm them using probiotics, but I think it's often true that the unhelpful bacteria must be knocked down first, before the friendly ones can be built up.
Will do, antibiotics is not an option here???
***Antibiotics are an option, but if used, they should be narrowly targeted at the bacteria to be knocked down, not broad-spectrum, and antibiotic use for a few days should be alternated with many more days of probiotics, in the manner that Dr. de Meirleir uses them. Otherwise, antibiotics can make the dysbiosis worse. Many PWMEs have dysbiosis because of improper use of antibiotics in the first place, in my (unauthorized) opinion.
I think that the reason you have IgG antibodies to several foods is that the gut dysbiosis has resulted in intestinal permeability ("leaky gut" syndrome), so if you can correct the dysbiosis, I think the food sensitivities will resolve. In the meantime, it is best not to eat the ones that you are sensitive to, and also to rotate your foods to avoid other sensitivities.
This is def my theory as well, all these foods were eaten at the time of the testing accept for the paranuts.Im following the Paul chek food rotation at the moment.
***O.K.
Your carbohydrate metabolism is not operating very well, judging by pyruvate being below the detection limit. This could be caused by a low-carb diet, poor absorption of carbs by the gut, or low magnesium.
I have been trying to go as low on carbs as possible to batle the gut problems.
***O.K. That may explain it. Hopefully you will be able to fix the gut problems and then will be able to resume some carb intake.
Normally, when carbs are not being supplied to the citric acid cycle at a normal rate, fatty acids are mobilized and the cells go into ketosis. However, in your case, this is not happening, based on beta hydroxybutyrate being below the detection limit. You have some omega oxidation of fatty acids going on, but not much. The fat stains on the stool test suggest that you may not be digesting or absorbing fats very well, perhaps because of the dysbiosis or because of bile insufficiency. It's not possible to say for sure what the cause is with the available data. You could also be low in carnitine or B2 or both.
The first three citric acid cycle metabolites are low because not much in the way of carbs or fats are being fed to the cycle.
Alpha ketoglutarate is below the detection limit. This is probably due to low B3, magnesium or manganese, as well as low B6 and/or B2. Succinate is normal, suggesting that you are feeding some branched-chain amino acid into the citric acid cycle. Fumarate is below the detection limit, perhaps due to B2 deficiency.
Correct, I have been using EAA
***O.K.
The high xanthurenate and kynurenate indicate low B6 or B2 or both. The high beta-hydroxyvalerate indicates a biotin deficiency.
The high formiminoglutamate indicates low folate. Although methylmalonate is not high, I suspect that you have a functional B12 deficiency, based on the high formiminoglutamate and the low pyroglutamate (which indicates glutathione depletion). The methylmalonate marker can be masked by B-vitamin deficiencies.
Should I supplement b 12?? Which one(brand) in that case???
Your neurotransmitter metabolites are off-normal. It's difficult to be specific about them, but they are affected by B-vitamins, and you do have deficiencies in at least some of them.
The high 8-hydroxy-2-dexyguanosine indicates oxidative stress that is damaging the DNA. This would be consistent with glutathione depletion.
Sounds serious????
I have been taking these supps, very expensive, anything you have heard of or is it just bogus???
http://www.lyposphericnutrients.co.uk/default.aspx
***Generally speaking, liposomal supplements are better absorbed than ordinary oral supplements. It is important to pay attention to the cautions on the website about hemochromatosis, glucose-6-phosphate dehydrogenase, etc.
Your detox system is working hard to try to take out toxins, but general disruption of the sulfur metabolism is hindering this. There is very low flow in the transsulfuration pathway, based on alpha-hydroxybutyrate being below the detection limit. Low B2 and/or B6 could be responsible.
I suspect that your urea cycle is not operating very well, based on both fumarate and orotate being below the detection limit. If we had an amino acids panel, I could say more about that.
Your cortisol and DHEA look pretty good.
So generally speaking, I agree with what others have said. The gut issues need to be dealt with first. Then the deficiencies need to be corrected, particularly B-complex vitamins and essential minerals, but it would probably be a good idea to take a good multivitamin-multimineral to cover all the essential ones. You will need to consume some good quality protein to supply the necessary amino acids, and some fish oil to supply essential fatty acids to repair your cell membranes, which will have been damaged by the oxidative stress.
If your methylation cycle and glutathione do not bounce back after these things are corrected, then I think you will need a methylation protocol that includes methylfolate and high-dose hydroxo or methyl B12, either sublingually or by injection.
I recommend that you work with a physician for treatment.
Best regards,
Rich Hi Rich!
I dont know how to ever thank you enough for such an amazing reply, but you will get plenty of good karma thats foo sho!
Ive answered above on your coments in bold style. When you say a physician, you mean a regular doctor then??
***Yes. It might be a challenge to find one who is experienced with treating gut dysbiosis and the methylation cycle, but hopefully there are some there. Last October I spoke in Sweden as a guest of the IAOMT group there. Maybe someone in that group could refer you to a physician who is familiar with these things.
Do you happen to know how I can contact them??
Maybe I should print all this info and bring it??
***You could certainly try that.
The liver problems are perhaps something I could take up with the healthcare??
***I'm not familiar with the "healthcare" in Sweden, but maybe so.
Im real new to this, how bad are my tests compared to a normal person???
***I would say a little worse than the average PWME I've seen, but certainly not as bad as some.
Oki, comforting But how do I explain to my family, friends, employer etc whats wrong with me?? Everyone just says that its nothing, that all is normal and that I am just depressed, extremely frustrating and I avoid people due to this, would be so helpful! also which threads in this forum should I study the most????
Can I still work out on the days I feel like I can or is this to stressing??
***I think you will be the best judge of what you can do. If you feel worse the next day, it was too much, and you will know that you should do less.
Ive seen you suggest a multi in other threads which I have ordered, was planning on rotate that one with another good one perhaps.
***O.K. There are quite a few good multis available, but the one-pill-a-day types are not adequate.
Also the carb factor, I read alot about carbs being the enemy, however I really do struggle without any carbs, I gain weight and get too tired If I live on meat, veggies and berries.
***Again, I think you will have to judge what works best for you. Normally, people do need some carbs to help maintain a good blood sugar level, which is important for the brain, especially. But in ME/CFS, carbs are not metabolized very well. Hopefully your gut and your methylation cycle function can be improved so that you will be able to have a more balanced diet.
Are Quinoa, beans and wild rice unthinkable with my kind of gut problems??
***I wouldn't say that. Again, I think you will be the best judge of that by how you respond to them. But I do urge you to work on getting your gut bacteria closer to a normal situation.
Thank you so much once again!! Theres a little hope again.
***You're welcome.
Pete
Ive tried hard
***I'm sure you have, and I hope it will pay off for you.
***Best regards,
***Rich
