Rats! I have to say I felt better after my second infusion (late November), then was having a lot more pain and whatnot in February. So, it could have been a return of B cells (don't know yet until my labs come in from last week, just before my 3rd round of Rituxan). I also have been doing a lot more than I was in the past, so it's hard to tell...What Rituxan is doing for me seems very strange. In the 1st month after infusion I start to feel better, maybe a 30% cut in sensitivity to allergies. Then after that month it slowly stops working until the end of the 2nd month I quickly get worse. As of now Im scheduled to get infusions every 2 months for I believe the next 6 months.