Results of my experiments placing various gut health supplements in special colon-targeted enteric capsules

[Hip]

Yesterday I took NAC covered in confectionary glaze and I noticed nothing odd about my condition, all within normal parameters no weird mental health issues. My colon is a bit tender at the moment but this hasn't made it worse.

Very interesting. I have not yet tried NAC in shellac-coated capsules, though have tried glutamine, N-acetyl glucosamine, vitamin A and zinc (all good for leaky gut). And also probiotics.

N-acetyl glucosamine (NAG) was the one that really had strong adverse mental health side effects when taken shellac-coated, so I think NAG may be having a strong effect in the colon.

NAG increases mucin secretion on the intestinal mucous membranes, and this can fight biofilms. The adverse mental effects I experienced from shellac-coated NAG might be due to some bacterial or biofilm Herx effect.

The Amazing thing is that when taking NAG in regular capsules (even in doses as high as 3000 mg), this never causes any adverse effects, and on the contrary, I find NAG beneficial for mental health symptoms like anxiety.

But as soon as I placed a 700 mg NAG capsule in shellac, to target the colon, it made a huge difference, and had strong adverse mental health effects (though no physical adverse effects).

 

[Hip]

One potential explanation for why shellac-coated N-acetyl glucosamine (NAG) caused me to experience adverse effects: the presence of NAG prompts the white cell form of Candida albicans to convert into the hyphal form. It is the invasive hyphal form of Candida which burrows into the intestinal lining, which can then cause leaky gut.

Though NAG also causes white Candida albicans (the most common type in the intestines) to convert to opaque Candida, and the opaque form is not able to convert into the hyphal form (see this post).

 

[Forummember9922]

@Hip Ive been trying NAG with possible improvements that could've been placebo,
But I bought a different brand of NAG and later realized its N Acetyl ‘D’-Glucosamine rather than just N Acetyl Glucosamine. Did you ever try both and notice any difference? AI says the D version is more relevant to human biological function but I perhaps found the regular NAG one from Source Naturals to be better

 

[Hip]

But I bought a different brand of NAG and later realized its N Acetyl ‘D’-Glucosamine rather than just N Acetyl Glucosamine.

I believe these are two names for the same supplement. Sometimes they include the D in the name, other times they drop the D, but they are both the same NAG.

 

[Forummember9922]

@Hip Ever get an almost heat sensation from NAG almost like bodys fighting something? I am privy that there are T cell effects just curious if you experienced this ? Happens when I go higher doses


Another interesting thing I learned is that N-A-G effects the urea cycle which is responsible for formation of Citrulline, Arginine

 

[Hip]

Ever get an almost heat sensation from NAG almost like bodys fighting something?

I have not noticed anything like that. I've taken up to 3 grams of NAG.

 

[Forummember9922]

TLDR- I like NAG, I like that it is related to gut health, and I have been doing better recently from possibly NAG (or Saffron or Tadalafil)

This is kind of rambling here,

But I thought of you today @Hip as I was pondering NAG, which you have touted, (And I am thankful for finding it).

Today I am having what is the first clear crash in a few weeks maybe a month, but I am not out of the woods. At no point have I felt completely healed even in that crash-free period. But I would have to contribute recent improvements to NAG, Saffron, or Tadalafil.

But what really got me thinking is how profound and non-stop the diarrhea has returned upon this crash, and it reminds me of how this whole mess we find ourselves in is in some way related to the gut.

I sat outside today and I looked down at my hand and see a tiny paper cut which, like other ones, is now turning into a deep scar. Why would the body want to over produce scarrous tissue? I am giving myself a lot of freedom to ramble here but to me it speaks to some compensatory mechanism for a leaky gut. IE, Body: "Let's build all the scarring we can to plug those leaks". Or maybe those are completely unrelated.

RE gut health aspirations I have also begun taking G-Niib/Sim01 which was not easily available in the USA until recently, as well as a 'Leaky gut repair' supplement- which typically contain Licorice (I am glad I see the DGL version is available), Aloe, Glutamine, Marshmellow, Zinc. I will also resume the beef intestines powder for my newfound passion to attempt to heal my gut.

 

[Wishful]

a tiny paper cut which, like other ones, is now turning into a deep scar.

Interesting. I'd gotten a sliver, and that's still a lump of scar tissue. I hadn't considered it being an ME-related issue. Is anyone else having abnormal scarring?

 

[Florida Guy]

I've seen enteric empty capsules on ebay but they cost close to a dollar each as I recall. They are used when a supplement will be destroyed by the acid in the stomach and needs to be absorbed in the small or large intestine. There are a number of drugs that can't be taken by mouth for that reason

Its interesting that people are reporting different effects using the shelac on capsules to take a given substance. Hip says he got a bad effect from something that used to help like glutamine when taken that way. Could the glaze itself have an effect?

Perhaps this could be used with peptides, some of which break down in the stomach and are usually injected?

One little trick I use with things that don't do well in the stomach acid is to take something on an empty stomach with a lot of water. Little or no acid will be formed since the body does not detect food and it will go down fast. I've used that with nattokinase which helps remove deposits from your arteries

I think we should all try different substances, different foods, vitamins, drugs and so on because people have found many things that help with symptoms. I found loads of home remedies for stubborn problems so look around

 

[EddieB]

I've seen enteric empty capsules on ebay but they cost close to a dollar each as I recall. They are used when a supplement will be destroyed by the acid in the stomach and needs to be absorbed in the small or large intestine. There are a number of drugs that can't be taken by mouth for that reason

Its interesting that people are reporting different effects using the shelac on capsules to take a given substance. Hip says he got a bad effect from something that used to help like glutamine when taken that way. Could the glaze itself have an effect?

Perhaps this could be used with peptides, some of which break down in the stomach and are usually injected?

One little trick I use with things that don't do well in the stomach acid is to take something on an empty stomach with a lot of water. Little or no acid will be formed since the body does not detect food and it will go down fast. I've used that with nattokinase which helps remove deposits from your arteries

I think we should all try different substances, different foods, vitamins, drugs and so on because people have found many things that help with symptoms. I found loads of home remedies for stubborn problems so look around

Agree with all your points. My method, I use these capsules in three sizes, placing one inside another for a tripling effect and a longer delay. Sizes 1, 0, and 00.
https://www.amazon.com/XPRS-Nutra-S...373635&sprefix=delay+capsules+,aps,874&sr=8-3

A single cap doesn’t have enough delay, at least for me. I’ve tested using peppermint as an indicator. With one layer, I can still detect peppermint in a burp ( I have horrid reflux). But with three layers I don’t. So delivery is somewhat further down. I suppose adding a shellac coating to this set up would send it further.

 

[Florida Guy]

Interesting. I'd gotten a sliver, and that's still a lump of scar tissue. I hadn't considered it being an ME-related issue. Is anyone else having abnormal scarring?

I got a mild scrape on my leg a year and a half ago and the mark is still clearly visible. It only bled a tiny bit I don't see why there would be any scar. The mark is not thick like scar tissue but never went away. In the past, a month or so and it would be gone but this looks like it will show for another year at least. Weird.