Read this before trying choline.

[linusbert]

My results came in: my Nitro-Tyrosine was 626 nmol/L where the laboratory upper limit was 630 nmol/L. Since on the day of the blood draw my allergies were not that bad and the measured level was right at the upper limit, I am inclined to believe it is related to my chemical allergies. It is quite possible that, on my worse days, the nitro-tyrosine would be over the upper limit, so I will definitely keep on eye on this blood marker in the future in spite of the high cost for the test.

i really would go for a round of hydroxocobalamin 500-1000ug or even above.
nitro tyrosine is a marker for nitro radical stress. HYDROXOcobalamin is basically like a direct detox to that kind of ROS as it binds with NO and prevents the excessive formation.
therefore it does not fix the root problem (if the root problem isnt a b12 deficiency) but it can help prevent further damage to your body.

Choline's main effect is on the liver.
The liver is where meds are metabolized.

I wonder what the effect that choline can have on the liver that worsens a condition.

Let me think about this.

has big effects on the liver, beyond that its important in the methylation pathways as methylgroup donor. and also acetylation as acetylcholin later.

 

[cristi_b]

i really would go for a round of hydroxocobalamin 500-1000ug or even above.
nitro tyrosine is a marker for nitro radical stress. HYDROXOcobalamin is basically like a direct detox to that kind of ROS as it binds with NO and prevents the excessive formation.
therefore it does not fix the root problem (if the root problem isnt a b12 deficiency) but it can help prevent further damage to your body.

My vitamin B12 was measured at 676 pg/mL which is above average, I also eat a lot of meat so there's no chance of developing a deficiency. I've tried hydroxocobalamin and it causes sympathetic activation: I sleep less and become very irritable so unfortunately I cannot take it. Since NO has antimicrobial properties I tend to believe that there's some pathogen somewhere and my body is producing excess amounts to handle the infection.

 

[linusbert]

My vitamin B12 was measured at 676 pg/mL which is above average, I also eat a lot of meat so there's no chance of developing a deficiency. I've tried hydroxocobalamin and it causes sympathetic activation: I sleep less and become very irritable so unfortunately I cannot take it. Since NO has antimicrobial properties I tend to believe that there's some pathogen somewhere and my body is producing excess amounts to handle the infection.

its not so much about a b12 deficieny , its therapeutical use of a vitamin. you use the NO binding properties. too much can create a very dangerous ROS species. which wreaks havoc in the body. but of course you get the side effects of a high dose vitamin like imbalances and stuff. which is sad.
but 700 seams like a good enough level. i guess the body is able t oconvert to hydroxocobalamin if in need.