I don't know where to start, I feel a bit overwhelmed. Freddd,you posted a symptom list on wrongdiagnosis and I think I will start there. I know once I get to talking about it, I will find a direction. Bear with me, I am on information overload. You said by the symptoms one presents with, it could help you with direction in surmissing the possible problem. That is what I need help with. Direction and details.
I went through your list and bolded what was pertinent to my own symptoms. Any comments further explaining are italiced under the bold highlighting.
SYMPTOMS, SIGNS AND CO-CORRELATES OF METHYLB12, ADENOSYLB12,
METHYFOLATE AND SELECTED COFACTOR DEFICIENCIES
LAST UPDATE -
Version 1.0, 07/13/09
mouth sensitive to hot and cold
For me, sensitivity occurs more with cold.
sore burning tongue
This was some years ago when my problems with health started.
beef-red tongue, possibly smoother than normal
It was fire engine red and seemed enlarged in the beginning. Now it is a purple color more than red, and I have chronic candidiasis I can't get rid of for the life of me.
sore mouth, no infection or apparant reason
In the beginning, but not currently.
teeth sensitive to hot and cold
Again, only to cold.
canker sores
I can't say I have never had them, but they have been thankfully few in a lifetime.
burning bladder (no UTI)
In the beginning, not currently. Guess I should define my meaning for current. Meaning no more than a year out.
painful urgency (no UTI)
burning urethra (no UTI)
In the beginning, not currently
burning muscle pain
Very mild currently, in the past, was devastating.
accumulating muscle pains following exertion
I used to be a runner and swimmer. There was a time in the past, when I began going through the three day post burn, and then it would go away.
sore muscles
Minimal currently. Not anything like it was in the past.
lack of muscle recovery after exercise
I didn't have a problem with recovery or muscles, until all of the sudden, this period was about six years ago. I don't train at all these days, and exercising, considering my reactions and lack of recovery is not something I have tested recently. I would like to start running again, but I didn't want to do things to early. And considering the events of this past week, I believe it is still too early to test my reactions. I work on my feet for many hours. I am fine with that. But as far as anaerobic exercise or the weight training I used to do, nada.
exercise does not build muscle
I did up until a certain point. My legs were svelte. Try as I might, I could only achieve a four and a half pack. And I never could get my shoulders and back to show the muscles. I should have had a lot more musculature for what I was doing.
extremely sore neck muscles reversing normal curvature of neck
In the beginning, I had a very sore neck with enlarged lymph nodes on the side and along the spine. It was never bad enough to change the curvature of my neck. I also had a mid back pain, muscular in nature, where I could no longer maintain a sitting position, and would have to lie down to stop the pain. Nothing of the sort currently.exercise deblitates for up to a week, making things much worse
Like I tried to describe earlier, there was a period about six years ago when all of this hit me. At that time, I wouldn't be able to recover for more than a week at times, and my health deteriorated exponentially during this time frame.
painfully tight muscles, especially legs and/or arms
So after that time period, I stopped all my running and training. Even after quitting, the pain and tightness did not relent until starting the methylation protocol in October.
frequent muscle spasms anywhere in body
Not everywhere or anywhere. Specific and repetitive. Hiccups being one of those spasms. My eyes would also twitch, and in the beginning, this occured daily, and multiple times daily. I have had very few, I can't say non existent, but very few twitches originating from my upper arms, back, etc. I most definately developed Restless Legs. Magnesium chloride has been most helpful in relieving these occurences, and I currently do not suffer these symptoms.
muscle pain especially around attachment points to bones
Only in the beginning, that six years ago period.
Eighteen severely tender muscle spots of FMS
Yes in the beginning, no currently.
Bursitis
dyspepsia - sick stomach, nausea, regurgitation, vomiting, bloating, not emptying
flatulence
Intermittent currently
altered bowel habits
Awful diarhhea and steathorrea that kicked off my episode six years ago.
abdominal pain
loss of appetite for meat, fish, eggs, dairy, the only b12 contining foods, nutrient specific anorexia
Actually, the opposite occured with me. I craved meat, eggs, and diary. I absolutely craved them. Unlike anything ever before. I have never been a vegetarian. I am a mid western girl. Weve got some of the best beef around.
intermittent constipation
Only after starting the methylation recommendations. Is intermittent. Seems to correlate with DMG supplementation, of which only lasted a couple of weeks and is now gone. Noticing transit time has slowed considerably. There was a point in time, where I could had 10-20 bm's a day. Seemed like a girl couldn't ever get off the toilet. 
intermittant diarrhea
In the beginning, there was nothing intermittent about it. Ugh.
irritable bowel syndrome
Crohns disease (direction of causality if any not established)
Celiac disease (direction of causality if any not established) - gluten sensitivity
Only correlation to diet. After the DMG/perilla/quecertin mix, that sensitivity doesn't seem as acute.
Dairy sensitivity
Only in large quantities.
sores, ulcers and lesions along entire GI tract or any part
anorexia
Bullimia
reduced libido - loss of sexual desire
There was a time, but not currently.
loss of orgasmic intensity
Definatley not.
unsatisfying orgasms
inability to orgasm
loss and/or change of genital sensations - "gloved" loss of sensation
burning genital skin sensation
unable to become aroused
reduced testosterone
MEN
erectile disfunction
low sperm count
poor sperm motility
Poor sperm quality
Zero sperm count
WOMEN
post partum depression
post partum psychosis
False positive pap smears, noncancerous cellular changes
Interestingly enough, those abnormal paps started occuring around the six year mark I have mentioned often. Prior to that period, not one abnormal. After, all abnormal.
menstrual symptoms
God awful thorughout entire life in which the pill made thousands of times worse. Talk about Sybil. Yeesh. Responded well to progesterone shots.
Frequent miscarriage
Three.
child with neuro tube defects
PMS
See above
paleness
Until I was in my thirties, yes I was a pasty white. Then all of the sudden, I was able to tan darker than most around me. I now realize this is the abnormal bronzing associated with some metabolic disorders, although the detail escapes me as of yet.rapid heart rate
Intermittent, some correlated with known infections, others were unexplained.
heart arythymias
My heart seems to throw PVC's and painful ones at that. Its either pVC's or spasms.
Only remediatable with vagal response. Carnitine, magnesium, and potassium seem to help.
shortness of breath
Very few episodes, although again, the six year mark, I seemd to develop pleurisy like symptoms. I treated with herbals of which it resolved. Had another bought with it a year later, in which Rifampin/Isoniazid among others in combo. Have never had a problem since.
heart palpitations
weak pulse
congestive heart failure
arteriosclerosis
Widespread pain throughout body
Hypothyroid (direction of causality if any not established)
13 YA I developed an unknown thyroiditis and a few years after that went through Hashimoto's like symptoms. Have not had a problem currently.
High homocysteine
High urinary MMA
dizziness - even unable to walk
vertigo
Again around that six year mark.
irritable
Throughout life, and unexplainable, and unavoidable.
depression
Intermittent, not so much currently.
SAD - Seasonal Affective Disorder
mental slowing
personality changes
I think I mentioned Sybil? Its been amazing, but with the start of methylation, I am definately improving overall.
chronic malaise
At one point, I would of categorized it as debilitating.
poor concentration
moodiness
Rollercoaster like, and could occur in an incredibly short time span. My mother used to call it the light switch.
tiredness
mood swings
memory loss
There doesn't seem to be any rhyme or reason to my memory loss. It is both short term and long term. At one time in my life, my colleages nicknamed me the "walking encyclopedia". I had photographic memory skills. Then that six year mark happened along.
listlessness
impaired connection to others
Does not occur now.
mentally fuzzy, foggy, brainfog
I had run out of ad b12 last week. I went three days without it. That was an eye opening experience. I most definately need that type of B12.
psychosis, including many of the most florid psychosis seen in literature, megoblastic madness
Alzheimer's
delirium
dementia
paranoia
Not so much currently as in the past.
delusions
hallucinations
Like seeing moving things out of the corners of your eyes? Light flashes, like lightning? No, don't believe they were TIA's. Flashes do not occur anymore.
strange "smells" that are not present like linen being ironed, burnt odors or tidal flats etc
Oh my gosh yes. People used to tell me it was my nose cause they couldn't smell anything.
strange "sounds" that are not present, rustlings, mummurings, detonations etc
Detonations again around that six year mark. I also heard radio.
deja vu experiences
Used to happen all the time, but not so much currently. my mother used to say, Dejavu's were a way a telling you were on track with where you were supposed to be. She had them too.
anxiety or tension
Typical type A, not so much anymore. Life altering health kinda chnages ones perspective on all the small stuff.
nervousness
At times, like a june bug.
mania
impaired executive function
cognitive impairment
memory impairment
Hypersensitivity to touch
This one was incredible to me. Even a massage was a god awful experience. There was a time in my life where i wouldn't allow anyone to touch my legs.
Hypersensitivity to odors
Like a bloodhound.
Hypersensitivity to tastes
Hypersensitivity to clothing texture
Hypersensitivity to chemicals
Throughout life. At that six year mark, exponential increase, and debilitating, especially when exposed to fertilizers, pesticides, or exhaust. Very much imporved currently.
Hypersensitivity to body malfunctions, symtoms
Hypersensitivity to sounds and noises
Hypersensitivity to light and visual stimuli
Hypersensitivity to blood sugar changes
Hypersensitivity to internal metabolic changes
Hypersensitivity to temperature changes
In the winter I am too cold, in the summer too hot.
Hypersensitivity to foods
Noticed a correlation to gluten when just starting the methylation recommendations. Have had minor reactions to milk. Nothing with eggs.
mild to extremely severe fatigue
continuous extremely severe fatigue
easy fatiguability
Again, there was a time when all I could do was sleep. I remember sleeping for 21 hours straight, and then getting up for a couple of hours, and going back down for another 12.
severe abnormal fatigue up to and including apparent paralysis leading to death
spastic paralysis
weakness
Not currently.
sleep disorders
non restorative sleep
lack of dreaming
Night terrors
Very few.
Prolonged hypnogogic state transitioning to sleep
Sleep paralysis
alteration of touch all over body, normal touch can be unpleasant and painful
alterations and loss of taste
alterations and loss of smell
loss of smell and taste of strawberries specifically
This is tough for me, because I remember strawberries tasting so good when I was younger, but now they taste like tart water. There is no sweetness.
loss or alteration of smell and taste of potato chips specifically
Again tough, because I don't eat many potato chips.
roughening and increased raspiness of voice, mb12 can smooth it outin mid word
Especially after waking or illness. Sound like a phone sex operator, so I have been told anyways.
blurring of vision - can be sudden onset and sudden return
dimmed vision - usually not noticed going into it because change can be very slow or present for life
The ad B12 was the first I used in implementing the methylation suggestions. One of the first things that blew me away was the colors and brightness at night. Instead of being monochrome, in which I hadn't really noticed, just associated it with a dimness of lack of clarity, the colors of things popped out at me at night. The stop lights were almost blinding to me.
Visual impairment can be seen; ophthalmological exam may show bilateral visual loss
I consider myself fortunate, especially in light of what I have learned recently. i have never had to wear glasses, and the loss in my vision instead of being 20/20, is 20/40.
optic atrophy
optic neuritis
optic neuropathy
centrocecal scotomata
My mother has these types of problems.
intolerance to bright light
Still currently, although not quite as severe as in the past.
diminished hearing - gradual onset or present for life, sudden return possible
unclear hearing, garbled
tinnitus - ringing in ears
always feeling cold
intolerance to loud sounds
intolerance to multiple sounds
inability to pick out one voice amongst many
Brainstem or cerebellar signs or even reversible (with mb12) coma may occur
neural tube defect not caused by folate deficiency or child with it
demyelinated areas on nerves
subacute combined degeneration
axonial degeneration of spinal cord
unsteadiness of gait
ataxic gait, particularly in dark
Not currently
positive Romberg
positive Lhermittes
neuropathies, many types
progressive bilateral neuropathies
demyelination of nerves - white spots on nerves on MRIs
loss of detail and sensual aspects of touch all over body
paresthesias in both feet - burning, tingling,cobwebs, wet, hairs, pain, numbness, etc
paresthesias in both legs - burning, tingling, cobwebs, wet, hair, pain, numbness, etc
paresthesias in both hands - burning, tingling, cobwebs, wet, hairs, pain, numbness, etc
paresthesias in both arms - burning, tingling, cobwebs, wet, hairs, pain, numbness, etc
Loss of position sense is the most common abnormality (or vibration sense)
Loss of vibration sense is the most common abnormality (or position sense)
Just prior to beginning the methylation suggestions, I was just beginning to experience these symptoms. None currently.
Loss of sense of joint position
hands feel gloved with loss of sensitivity
feet feel socked by loss of sensitivity
trembling
neuropathic bladder
unable to release bladder, mild to severe
urinary incontenance - occasionally to frequently
fecal incontinance - occasionally to frequently
sudden electric like shocks/pains shooting down arms, body, legs shooting down from neck movement
Not many incidents, although I cannot claim unexistent.
standing with eyes closed, a slight nudge or bump causes loss of balance
Also loss of balance, couldn't stand on one foot if my life depended on it. That still occurs currently, although now, it seems to be intermittent.
most patients have signs of both spinal cord and peripheral nerve involvement
The effect on reflexes is quite variable
Motor impairment may range from only mild clumsiness to a spastic paraplegia
clumsiness
slowed nerve impulses
Opposite, mine were over reactive.
decreased reflexes
difficulty swallowing
Not currently
brisk reflexes
Throughout life.
decreased deep tendon reflex
toes turn up instead of down in reflex to sole stimulation
I thought it was normal.
Positive bilateral Babinski reflex
Foot Drop
If you mean that when you are walking, and you trip over your own toes and upper foot because all of the sudden it won't work, yes. Not so much after methylation began.
impaired white blood cell response
I suspect due to suspectability to infections.
poor resistance to infections
Throughout life and currently.
easy bruising
Still currently.
pronounced anemia
macrocytic anemia
megablastic anemia
pernicious anemia
I suspect this heavily.
decreased blood clotting
Yes, a cut will just keep on bleeding.
low hematocrit
Actually, mine was abnormally high from test results near that six year period mark. I have nothing current.
MCV > 92-94 first warning, MCV > 97-100 alert
elevated MCH (Mean Corpuscular Hemoglobin)
elevated LDH
big fat red cells (when said this way usually with happy or healthy modifying it completely misinterpreting results of MCV
platelet dysfunction, low count
white cell changes, low count
hypersegmented neutrophils
migraine headache cycles
The kind that could make you throw up but you couldn't because it would simply just hurt too much. Like someone pulling on the backs of your eyeballs. When I was younger, I would only get this in my right eye. Then they began to occur in both eyes, but rarely at the same time. Not so much currently.
headaches
inflamed epithelial tissues - mucous membranes, skin, GI, vaginal, lungs, bladder
inflamed endothelial tissues - lining of veins and arteries, etc
high CRP without infection
mucous becomes thick, jellied and sticky
dermatitis herpetiformis, chronic intensely burning itching rash
frequent infected follicles
Seborrheic dermatitis
dandruff
eczema
dermatitis
skin on face, hands, feet, turns brown or yellow if anemia occurs
My son and I both, get yellow hands or feet or both. Intermittent.
poor hair condition
thin nails
transverse ridges on nails, can happen as healing starts
splits/sores at corners of mouth
Hyperhidrosis - excessive sweating
I didn't thoughout my life until this six year mark happened.
Bariatric surgery
glutathione, glutathione producing supplements such as NAC/glutamine
I have taken NAC in the past.
Dilantin,
tegretol and some other medications
Relatives, grandparant, parent, sibling, child, grandchild ever needing b12 shots or supplement
coma
seizures
brain atrophy with ileal tuberculosis preventing b12 absorbtion
STARTING AS INFANT OR CHILD
delayed myelination
failure to thrive
autism
delayed speech
depression
frequent or continuous toncilitis
frequent strep
frequent pneumonia
frequent longlasting supposed viral illnesses that linger and linger and linger
everything goes to the lungs for extended periods
Never been diagnosed with pnuemonia. It always went to my chest but did not linger for extended periods.
headaches
growing pains
I remember the bone pain, and my son went through it too.
skin problems
I had porcelain skin and was thankfully not plagued by teenage acne. Except for one occurence at the age of 13 in which lasted for four months and disappeared until my mid thirties.
dandruff
allergies
Never had allergies until my mid thirties, then went from nothing to everything all the time. Warranted a script for year round antihistamines.
asthma
continuous swolen glands in neck
low grade fever for years
Prior to developing overt illness, I ran a low grade fever for two years. I also had erythema over my thymus on my chest for that time as well. Although pointed out to docs at the time, went undiagnosed.
Night terrors
Prolonged hypnogogic state transitioning to sleep
Sleep paralysis
seizures
coma
Read more at
http://forums.wrongdiagnosis.com/showthread.php?t=62327&highlight=active+b12+basics&ktrack=kcplink
