Going by some of the other comments of the user it seems possible that it's a troll. The answer of Prusty regarding the role of Drp1 of course stays extremely relevant.Searched but haven't found anything that made sense
Going by some of the other comments of the user it seems possible that it's a troll. The answer of Prusty regarding the role of Drp1 of course stays extremely relevant.Searched but haven't found anything that made sense
Finally, it was also part of a treatment that was partially successful https://sci-hub.se/https://doi.org/10.1016/j.mehy.2018.08.014 even though this treatment is not really confirmed and could be b.s. It was Frank Comhaire’s treatment with sodium dichloroacetate (DCA) to increase pyruvate dehydrogenase (PDH) which allegedly works well for some, but not for others.
Seems worth a try and thank you for all this info I will try some DCA myself but for the sake of argument doesn't Prusty's magical mystery molecule require bone marrow involvement eh? I believe other therapeutic implications RE PDH would be ALA and Carnitine ? I hope we are not derailing too far Cool stuff
- Prusty’s 2020 paper mentioned the down regulation of this protein.
- It has often / previously appeared in the ME/CFS literature (https://pubmed.ncbi.nlm.nih.gov/28018972/). Pyruvate dehydrogenase deficiency causes many problems including lactic acidosis, progressive neurological and neuromuscular degeneration and if it’s induced by a genetic mutation (not a reactivated virus) death during childhood https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003492/. As such it is something that has been found before, but maybe only he was able to connect the dots as he mentioned in his interview?
- Furthermore, it’s stimulation reverses the induction of itaconate https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.3MR0322-692RR.
- Finally, it was also part of a treatment that was partially successful https://sci-hub.se/https://doi.org/10.1016/j.mehy.2018.08.014 even though this treatment is not really confirmed and could be b.s. It was Frank Comhaire’s treatment with sodium dichloroacetate (DCA) to increase pyruvate dehydrogenase (PDH) which allegedly works well for some, but not for others.
for the sake of argument doesn't Prusty's magical mystery molecule require bone marrow involvement eh?
he doesn’t say C1q is high in MECFS patients. he has found high levels of anti-C1q autoantibodies which target C1q. therefore C1q is low in MECFS patients. he also mentions there is published research that exercise decreases C1q which could explain PEM.Maybe the ideas are outdated so forgive me if I am going back in time. C1Q is shown to be higher in CFS patients so that would not be the missing protein. I bring it up for thought because methods used to address c1q issues can be stem cells or bone marrow transplants and he mentioned bone marrow is a key factor. Some discussion on c1q was had on phoenixrising already when these findings came out.
To be honest I, myself, don't think it's PDH, C1q or any of the other things that have been mentioned here. But I think having the discussion is interesting and after all that is what Prusty wanted.Seems worth a try and thank you for all this info I will try some DCA myself but for the sake of argument doesn't Prusty's magical mystery molecule require bone marrow involvement eh? I believe other therapeutic implications RE PDH would be ALA and Carnitine ? I hope we are not derailing too far Cool stuff
He was saying that his HHV reactivation / mitochondrial breakdown model can explain all pathologies found in ME/CFS because this can occur in any cell. I think his mention of the bone marrow is simply speculation on the possible mechanism of how this may cause immune dysfunction. If HHV6 is reactivated in the bone marrow then immune cells that are produced there will be dysfunctional or there will not be enough of them produced.He didn't give much away, but he does say this:
"the bone marrow is the key because the source of the cells is the bone marrow"
idk, maybe this is about a protein deficiency in platelets, or b-cells, or monocytes?
I think he mentioned he would have a paper by the time he speaks on it in 2-3 weeks, or I could have been hearing things...From what he said it sounds like it could be a protein thats produced by cells which originate in the bone marrow, but perhaps this protein could circulate and affect the whole body, or other parts of the immune system ? its going to feel like a long wait to find out what his paper says.
How would you square up the similarities between long covid and mold?The original 'CFS' epidemics or at least Lake Tahoe was partly caused by toxic mold behaving in an unusual way, corrupt doctors came in and tried to pin the blame solely on viruses when not every patient in the epidemic had elevated EBV, this was probably part of a wider agenda to put the worlds attention onto viruses for unknown reason. It is possible however that what most people with ME/CFS suffer is caused by virus with no involvement of mold, but if so I believe its likely a different disease that the original 'CFS' from Lake Tahoe, this is all explained by Erik Johnson. Its also possible that the onset of this process supposedly discovered by Prusty requires toxic mold exposure to create the precursor state required. One of the 'poster childs' of ME/CFS Jenn Brea actually turned out to have toxic mold as the root cause of their illness, which then lead to CCI and therefore MECFS symptoms. I think we should be cautious about going tunnel vision about viruses, as I initially had the standard presentation but 3 years into the illness I noticed strong reactions to a wooden building in the garden that had rapidly become a bit moldy due to water damage. 5 years + into the illness the mold specific symptoms started to appear and I got much worse, i'm notwdoing total mold avoiidnce and living in a tent and my more recent neurological symptoms have greatly improved, but still have many of the limitations I developed in recent months, though stabilized or slightly improved. Bear in mind what he says, this treatment is complex... whereas considering if mold is a factor is easier to do and test.
between long covid and mold?
I'm not disputing it. Just asking the question. I'm sure mould plays a part for some. But is it the main causeperhaps nobody has yet analyzed mold exposure in long covid victims.
In case people haven’t seen it yet. The schedule for the Berlin conference has been uploaded (https://cfc.charite.de/fileadmin/us...age/MECFS-Conference-2023-Final-Programme.pdf). Prusty will be speaking on the 11 May at 17:10, following some other EBV talks. It’s a very short 20 minute talk (as are the others). Several of the leading researchers from around the world will be speaking.