Rufous McKinney
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Being told I have low grade B cell lymphoma make sense, correct? Its like a fingerprint for all this?
Does your ME/CFS come from EBV? EBV certainly goes along with lymphoma. WHO says it's a carcinogen.Its like a fingerprint for all this?
Does your ME/CFS come from EBV?
Don't be sorry. Announce away. I hope you're being supportedI am sorry to have just so abruptly announced that. I guess one method of coping is to simply Announce the Worst News, and figure it can only improve from here.
What I would like to know is, why isn't the condition passed from person to person via contact. If you have reactivated heroes why does somobe else's immune system work better.I believe this is the first presentation (May 11 or 12).
The Reddit post is a summary of the interview and Dr. Prusty's theory. I quoted it below to save people a click. Make sure to click expand to read the whole thing.
I think he said the defective cell-autonomous response to HHVx could be genetic. Whether this leads to disease is random (depends on the tissue where the reactivation occurred)What I would like to know is, why isn't the condition passed from person to person via contact.
Well, unless you are a vampire...why doesn't this happen to loved ones during intimacy
It's like HIV...possible to contract through sex..so why not this.Well, unless you are a vampire...
Hoping all this will be explained in the presentation.
Could defective thing be a subset of collagen expression?I think he said the defective cell-autonomous response to HHVx could be genetic. Whether this leads to disease is random (depends on the tissue where the reactivation occurred)
As I understand, with ME/CFS it's not the virus, but the body's response to the virus, especially the innate immune system. With HIV etc, it's the virus itself that is being passed as well as causing the problem. 90% of adults have EBV, but only some of those get ME/CFS from it.possible to contract through sex..so why not this.
List all proteins that are in any way related to Drp1 or interact with it or are in the same pathway
Drp1 (dynamin-related protein 1) interacts with various proteins and is part of a complex network of pathways related to mitochondrial dynamics, including fission, fusion, and quality control. Here is a non-exhaustive list of proteins that are related to Drp1 or interact with it, or are in the same pathway:
There are many other proteins that could interact with or regulate Drp1 in various cellular contexts, and the list above is not exhaustive. The understanding of the relationships and interactions between these proteins is constantly evolving, and more research is needed to fully elucidate the complex network of pathways involving Drp1.
- Fis1 (Mitochondrial fission 1 protein): A protein on the outer mitochondrial membrane that helps recruit Drp1 to the mitochondria during fission.
- Mff (Mitochondrial fission factor): Another protein on the outer mitochondrial membrane involved in Drp1 recruitment for mitochondrial fission.
- MiD49 (Mitochondrial dynamics protein 49): Involved in Drp1 recruitment and regulation of mitochondrial fission.
- MiD51 (Mitochondrial dynamics protein 51): Similar to MiD49, involved in Drp1 recruitment and regulation of mitochondrial fission.
- OPA1 (Optic atrophy 1): A protein involved in mitochondrial fusion, mainly responsible for the fusion of the inner mitochondrial membrane.
- MFN1 (Mitofusin 1) and MFN2 (Mitofusin 2): Proteins responsible for the fusion of the outer mitochondrial membrane, counterbalancing the fission process driven by Drp1.
- PINK1 (PTEN-induced kinase 1): A kinase involved in mitochondrial quality control, which phosphorylates several proteins, including Drp1, to regulate fission and mitophagy.
- Parkin: An E3 ubiquitin ligase that works together with PINK1 in mitochondrial quality control and mitophagy.
- SUMO (Small ubiquitin-like modifier): A family of proteins that can post-translationally modify Drp1, affecting its function and regulation.
- Calcineurin: A protein phosphatase that can dephosphorylate Drp1, modulating its activity in response to changes in cellular calcium levels.
List all commercially available drugs that are in any way related to any of these proteins
Several commercially available drugs have been found to affect or interact with the proteins mentioned in the previous response, which are involved in mitochondrial dynamics and function. The following is a non-exhaustive list of such drugs:
- Cyclosporine A: An immunosuppressive drug that inhibits calcineurin, affecting its ability to dephosphorylate Drp1 and modulate mitochondrial dynamics. It is used to prevent organ transplant rejection and to treat certain autoimmune diseases.
- FK506 (Tacrolimus): Another immunosuppressive drug that inhibits calcineurin, similar to Cyclosporine A. It is used for organ transplant rejection prevention and in the treatment of certain autoimmune diseases.
- Mdivi-1 (Mitochondrial division inhibitor 1): A small molecule inhibitor of Drp1, which has been investigated for its potential neuroprotective effects. Although it is not yet an approved drug for any specific condition, it is commercially available for research purposes.
- NIM811: A non-immunosuppressive cyclosporine A analog that has been shown to inhibit mitochondrial permeability transition and protect against ischemia-reperfusion injury. It is currently in the experimental stage and is not approved for clinical use.
- S1R agonists (e.g., pridopidine): Sigma-1 receptor (S1R) agonists have been shown to modulate Drp1-dependent mitochondrial fission. Pridopidine, an S1R agonist, is under investigation for potential use in treating neurodegenerative diseases like Huntington's disease and Parkinson's disease.
yup- lifetime of EBV. at least sixty years...editted to add: I also blame the orchards..the organophosphates