(POLL) Which of the following viral/bacterial infection tests have you had?

[Hip]

For example, if ME is due to an abortive viral infection hiding in the hypothalamus cells, what tests will reveal that, and what treatments will target that properly?

That's where I believe Dr Lerner's viral testing criteria come in useful, because these were aimed at detecting abortive herpesvirus infections.

In this paper, Lerner says:

Both D (diffuse) and R (restricted) components of EBV early antigen (EA) indicate abortive nonpermissive incomplete virus replication to about the first 50 early genes of sequential early and late genes in the cascade of the complete genome (Figure 1).

In this paper he says:

We propose that ME/CFS patients have nonpermissive herpesvirus (EBV, HCMV, HHV6) replication, expressing immediate-early (IE) gene products, which induce host cell dysregulation and host cell apoptosis.

So it is the immediate-early gene products which seem to be markers for abortive infection, according to Lerner.



Note that in his studies Lerner calls abortive infections "nonpermissive infections", but strictly speaking, nonpermissive describes a cell type — which when infected leads to an abortive infection. However, many other researchers seem to use "nonpermissive infection" to mean "abortive infection".

 

[Wishful]

So it is the immediate-early gene products which seem to be markers for abortive infection, according to Lerner.

Do those products show up in blood samples, or just CSF samples, or just in tissue samples? I'm guessing that this isn't at the stage where I can go to a small-town Canadian medical clinic and ask for those tests. Furthermore, I expect that right now there are only a few specialists who could interpret the results properly, and I'm not sure whether any of them can actually recommend something based on them. There's also the question of whether timing of the samples is important; maybe those products are released 36 hrs before a flare-up of symptoms, or 8 hrs after.

It's certainly an interesting theory, but it's too early in the process to make an appointment for tests.

 

[Hip]

Do those products show up in blood samples, or just CSF samples, or just in tissue samples?

I believe Lerner just used blood serum, which is normal for antibody tests.

 

[pattismith]

I m Also positive for yersinia enterlitica and B hepatitis.

The positivity rate in your pool is about 4,5 per people, I wonder if it's a normal rate if you compare to the general population.