Paradoxical effect after methylfolate and B12

[Methyl90]

It seems that after using methylfolate and B12 I am undergoing a state of hypomethylation ... mostly I have lost muscle mass. It's normal ? Could taking TMG or Sam-e help if B12 and folate deficiencies have been restored?

 

[LINE]

Pathways can be tricky, hacking is the way to go. By this I mean you have to find the missing link. I usually start with the vitamin co-factors then specific minerals and by specific aminos. I would look at the other b vitamins since tipping the scale with specific ones (folate, B12) can cause suppression of the other b vits.

Everyone is individual so you never know what you get but I like B2 and B6 but never neglect the others. Muscle loss is usually a catabolic reaction where the body is using the proteins from muscle to keep the machine going. There is a pathway called the alanine cycle that explains this, but this may not explain it either.

 

[Methyl90]

Pathways can be tricky, hacking is the way to go. By this I mean you have to find the missing link. I usually start with the vitamin co-factors then specific minerals and by specific aminos. I would look at the other b vitamins since tipping the scale with specific ones (folate, B12) can cause suppression of the other b vits.

Everyone is individual so you never know what you get but I like B2 and B6 but never neglect the others. Muscle loss is usually a catabolic reaction where the body is using the proteins from muscle to keep the machine going. There is a pathway called the alanine cycle that explains this, but this may not explain it either.

What do you think if you initially only increased animal protein?

 

[Crux]

Are you getting enough choline ?
Low choline intake can cause muscle loss.

 

[Methyl90]

Are you getting enough choline ?
Low choline intake can cause muscle loss.

On some days I have negative neurological effects from too much dietary choline ... I don't think that's the missing link. If glucose metabolism is impaired, acetylcholine will not be produced on a regular basis, so using vitamins, minerals and cofactors could only worsen general homeostasis.

 

[Methyl90]

Pathways can be tricky, hacking is the way to go. By this I mean you have to find the missing link. I usually start with the vitamin co-factors then specific minerals and by specific aminos. I would look at the other b vitamins since tipping the scale with specific ones (folate, B12) can cause suppression of the other b vits.

Everyone is individual so you never know what you get but I like B2 and B6 but never neglect the others. Muscle loss is usually a catabolic reaction where the body is using the proteins from muscle to keep the machine going. There is a pathway called the alanine cycle that explains this, but this may not explain it either.

In the morning at the points of attachment of the bones I hear noises but without pain ... what can it be related to?