P2X7 receptors, is it safe to block it?

Hip

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You are referring to @necessary8's purinergic ATP signaling hypothesis of ME/CFS?

Some potential P2X7 inhibitors are listed in this post, but I calculated in this post that most of these inhibitors will not be effective in vivo when you take them orally. So there don't appear to be many P2X7 inhibitors available to ME/CFS patients anyway. I calculated that high dose transdermal magnesium may have some P2X7 inhibition (high dose transdermal or injectable magnesium is an old well-known treatment of ME/CFS).