Oxaloacetate. I am joining a study. Maybe you want to try

[Hip]

I’m wondering if anyone can clarify if oxaloacetate inhibits ketosis.

I don't know, I am afraid. I know very little about this supplement.

 

[helen1]

I don't know, I am afraid. I know very little about this supplement.

@Hip
I’m shocked, truly shocked lol.

I think I’ve figured it out though which is that low oxaloacetate is indeed needed for ketosis, so taking supplementary oxaloacetate is counterproductive to ketosis.

 

[Springbok1988]

I took this probably a year ago and only found a mild benefit that went away after several days. Not worth how expensive it is, in my experience.

 

[maverick76]

This guy sounds like a charlatan, but David Kaufman seems legit and was skeptical at first. He is now a big proponent. At the optimal dosage, the cost seems ludicrous. However, I may give it a shot just to see if there is any benefit. If there is, I'd be satisfied and hopeful that it would become FDA approved knowing that there is something out there. I'm not bedridden and have a job, so, I'd I have been waiting 20 years for something this promising, I can wait another 1-2 years for FDA approval instead of paying $500+ a month.

 

[parabola]

I know it's an old thread but to anyone considering trying this please be cautious, especially if you experience seizures or suspect calcium channel involvement

My story of oxaloacetate provoking a seizure

 

[MonkeyMan]

Someone posted in the health rising comments https://benagene.com/product/oxaloacetate-cfs-90-count-bottle each pill is 500mgs of oxaloacetate no vitamin c or other additives, $499 for 90

FYI, this is different from the Benagene oxaloacetate supplement you can buy on Amazon. The stuff available on Amazon has a much lower dose of oxaloacetate, and has added Vitamin C. The "CFS" product is not available on Amazon (at least I can't find it there), and is much more expensive, with a much higher dosage of oxaloacetate, and no Vitamin C.

 

[kushami]

I didn’t see the publication linked to previously in this thread, so thought I would add it:
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03488-3

I’m afraid there is a statement from the journal warning that the study is being investigated due to possible failure to declare competing interests and some other concerns.

 

[Dysfunkion]

FYI, this is different from the Benagene oxaloacetate supplement you can buy on Amazon. The stuff available on Amazon has a much lower dose of oxaloacetate, and has added Vitamin C. The "CFS" product is not available on Amazon (at least I can't find it there), and is much more expensive, with a much higher dosage of oxaloacetate, and no Vitamin C.

Im trying it anyways, 100 mg extra C wouldnt hurt me since I never had a bad reaction to C. I remember a while back I had to work my way up to 1000 mg daily.

 

[SpinachHands]

Just seen this in the ME association research roundup, is this a repeat of Kaufman's study back in 2021, or a new one testing the same thing?
https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1483876/abstract

 

[PaulDB]

Just seen this in the ME association research roundup, is this a repeat of Kaufman's study back in 2021, or a new one testing the same thing?
https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1483876/abstract

They've upped the dosage to 2,000 mg and found it to be well tolerated (some nausea and headaches reported). These results convinced me to try it, and so far it's been nothing short of astounding! If this continues, it's well worth the astronomical price being charged on Amazon.