Its been many years since I looked at HC.. but I just googled and found a bit I looked it and I'll copy it here
"Ved HS, et al.
> > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=2473427&dopt=Abstract
> > Effect of hydrocortisone on myelin basic protein in developing primary brain cultures.
> > Neurosci Lett. 1989 Apr 24;99(1-2):203-7.
> > [PubMed - indexed for MEDLINE]
> > PMID: 2473427; UI: 89314566.
> > Effect of hydrocortisone on myelin basic protein in developing primary brain cultures.
> > Ved HS, Gustow E, Pieringer RA
> > Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140.
> > The hormones hydrocortisone (HC) and triiodothyronine (T3) are known to regulate myelinogenic parameters in cultures of brain cells. However, the effect of glucocorticoids on the myelin-specific metabolite, myelin basic protein, has not been previously studied. In the present studies we show that the concentrations of myelin basic protein (MBP) in developing primary cultures from mouse cerebra are significantly higher in HC (0.3 microM)-treated as compared to untreated cultures after 15 days in vitro. Further, this effect of HC on MBP appears to be T3-dependent. Since HC stimulates oligodendroglia to produce MBP, the effect of HC on the activities of the enzymes, glutamine synthetase which is primarily associated with astrocytes, and acetylcholinesterase, which is primarily associated with neurons was was determined. HC stimulated both enzymes, suggesting that all 3 cell types may be regulated by HC."
I THINK from memory you'll find (but check it with google) that acetylcholinesterase breaks down T3 (thyroid hormones)..or does something to it!
This study is just one that shows how HC works WITh T3 and regulates T3 (or helps in its use ..that's actually what it does feel like speaking from self experience), In utilising the T3 the T3 gets used up...as expected? This is entirely different in feeling to not having the cortisol and not having the T3. The T3, I assume is converted to T2 etc..
At least back many years ago when I looked there was not much RT3 studied...couldnt even get ranges in Oz of it and I found it diffuclt to get tested!
I've always thought a simplified view of T3 and RT3 in the body like a car with an accelerator (T3)and a brake (RT3)- really you DO need both in a car, and you do need both in our body. Nothing wrong with a brake in a car and nothing wrong with RT3 in our body either! Yes RT3 is like an inhibitor of T3 (it seems folk here understand inhibitors and binding) as they "bind"probably in similar places and the Rt3 would prevent the T3 from working...but hey that's precisely what our bodies need MOST of the time this happens. I'm not saying that the brake can't get jammed sometimes or in a bind and need unsticking or a bit of help due to toxicities in the body or something going wrong... just usually we do nned both and usually its just fine and what you need!
Rt3 will increase when the body needs to slow down..as in illness so the body can rest and repair, its what it was designed to do..or at least that's my understanding. I'd expect(but have no idea other than a tealady-hypothesis) RT3 to increase therefore when there is some danger if the body metabolism runs at too fast a speed for the substrates it has...like say if cobalamin was in short supply, or folate or both, or iron(ferritin). The RT3 may increase as a self defense mechanism until the substrates can be found..rather than depleting them even more to dangerous levels. (please read free RT3 and free T3 where I typed T3 and RT3. )
So if your low on B12, you'd kinda expect RT3 is to highish..at least that's my hypothesis
I think its a known that RT3 is high in starvation(to slow doen and conserve fuel I'd expect) , but check it as my memory is not great! (that would fit with trying to slow the body down until it gets enough food).
edited to add: That view is simpified to the point of being incorrect, but better than what is around the web usually I think. However IF you want to understand more and have an interest and time, try reading this paper
http://ro.uow.edu.au/cgi/viewconten...oidhormone,+is+sometimes+more+potent+than+T3"
There's references to papers where RT3 is more potent in some sitiuations that T3, and some of the known (at that time, year 2000) breakdowns of T4..including T4.
Then there's a great paper of the differing deiodinases,
http://findarticles.com/p/articles/mi_m0FDN/is_4_5/ai_65068470/?tag=content;col1
over 30 pages if you want to read it! Its written in 2000, so much has been discovered since (google on thryoid hormone deiodinases)... theres all the is it conjugates of thryoid hormones also..like sulfonation, nitration, hydroxylation, the thryoid amine etc ..which speed or slow down , change function etc Its a huge , mostly unknown ..and not able to be fully understood by me in my lifetime stuff, so just looking at RT3 and T3 is really over-simplistic to be meaningful , but I guess a start?
Here's some other abstracts ..just to get an idea
http://www.ncbi.nlm.nih.gov/pubmed/20051527
Maybe its best looked at like temperature. We get a fever in RESPONSE toi something. Its a life saving mechanism to aid our bodies, but sometimes we need to step in and reduce it. I look at RT3 the same way maybe and cortisol (both I thiink) could be viewed as coping responses to something going on. Yes we all have some Rt3 , we are supposed to have, and we all have a temperature as well. Its the level, and its a response.
end of edit.
Also growth hormone increases T3...and exercise (especially when fasting,say in the morning before you eat breakfast increases growth hormone), so one fairly easy way I'd hazard a guess of increasing T3 to RT3 ratio is to start exercising for a couple of hours each morning?..safe way too. (i think there are studies on that..or some people starting to think that way)
It's what humans used to do before the modern time..get up hunt/gather/milk the cows, farm etc ..then cook breakfast (after separating the milk/cream, baking the bread, fetching the egges etc). Not get up and eat straight away. People who get up and say go for a run or row etc in the morning usually stay lean and have high growth hormone, and probably don't have a high Rt3 unless there is something wrong with them like an illness...
just a thought, and something I think may be starting to catch on.
eating many times a day I suspect increases RT3, I think we are not really designed to do this if ou look at the native communities. Feasting occasionally was more the norm.
The growth hormone /T3 is in a study somewhere- the rest is just observation I've made over the years and guesswork, I could be wrong but its my personal belief.
http://thyroid-insulin.blog.co.uk/2006/08/30/growth_hormone_stimulates_conversion_of_~1081430/
link chosen as is on folate, homocysteine, growth hormone etc...
Hope this helps- my thoughts higher levels of cortisol , and higher RT3 is are coping reactions, usually just what we need , but they may imply something is stressing us in some way
Adding a SR T3 would be expected help the T3: RT3 ratio and may sometimes be of benefit (but its something like a last resort really), although I have myself personaly done it- out of desperation I guess (scrip from a german trained GP...they study metabolism more over there than in Oz I think). As above shows there are other things to trial first that will change the ratio. Hopefully stepping down now...
"Ved HS, et al.
> > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=2473427&dopt=Abstract
> > Effect of hydrocortisone on myelin basic protein in developing primary brain cultures.
> > Neurosci Lett. 1989 Apr 24;99(1-2):203-7.
> > [PubMed - indexed for MEDLINE]
> > PMID: 2473427; UI: 89314566.
> > Effect of hydrocortisone on myelin basic protein in developing primary brain cultures.
> > Ved HS, Gustow E, Pieringer RA
> > Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140.
> > The hormones hydrocortisone (HC) and triiodothyronine (T3) are known to regulate myelinogenic parameters in cultures of brain cells. However, the effect of glucocorticoids on the myelin-specific metabolite, myelin basic protein, has not been previously studied. In the present studies we show that the concentrations of myelin basic protein (MBP) in developing primary cultures from mouse cerebra are significantly higher in HC (0.3 microM)-treated as compared to untreated cultures after 15 days in vitro. Further, this effect of HC on MBP appears to be T3-dependent. Since HC stimulates oligodendroglia to produce MBP, the effect of HC on the activities of the enzymes, glutamine synthetase which is primarily associated with astrocytes, and acetylcholinesterase, which is primarily associated with neurons was was determined. HC stimulated both enzymes, suggesting that all 3 cell types may be regulated by HC."
I THINK from memory you'll find (but check it with google) that acetylcholinesterase breaks down T3 (thyroid hormones)..or does something to it!
This study is just one that shows how HC works WITh T3 and regulates T3 (or helps in its use ..that's actually what it does feel like speaking from self experience), In utilising the T3 the T3 gets used up...as expected? This is entirely different in feeling to not having the cortisol and not having the T3. The T3, I assume is converted to T2 etc..
At least back many years ago when I looked there was not much RT3 studied...couldnt even get ranges in Oz of it and I found it diffuclt to get tested!
I've always thought a simplified view of T3 and RT3 in the body like a car with an accelerator (T3)and a brake (RT3)- really you DO need both in a car, and you do need both in our body. Nothing wrong with a brake in a car and nothing wrong with RT3 in our body either! Yes RT3 is like an inhibitor of T3 (it seems folk here understand inhibitors and binding) as they "bind"probably in similar places and the Rt3 would prevent the T3 from working...but hey that's precisely what our bodies need MOST of the time this happens. I'm not saying that the brake can't get jammed sometimes or in a bind and need unsticking or a bit of help due to toxicities in the body or something going wrong... just usually we do nned both and usually its just fine and what you need!
Rt3 will increase when the body needs to slow down..as in illness so the body can rest and repair, its what it was designed to do..or at least that's my understanding. I'd expect(but have no idea other than a tealady-hypothesis) RT3 to increase therefore when there is some danger if the body metabolism runs at too fast a speed for the substrates it has...like say if cobalamin was in short supply, or folate or both, or iron(ferritin). The RT3 may increase as a self defense mechanism until the substrates can be found..rather than depleting them even more to dangerous levels. (please read free RT3 and free T3 where I typed T3 and RT3. )
So if your low on B12, you'd kinda expect RT3 is to highish..at least that's my hypothesis
I think its a known that RT3 is high in starvation(to slow doen and conserve fuel I'd expect) , but check it as my memory is not great! (that would fit with trying to slow the body down until it gets enough food).
edited to add: That view is simpified to the point of being incorrect, but better than what is around the web usually I think. However IF you want to understand more and have an interest and time, try reading this paper
http://ro.uow.edu.au/cgi/viewconten...oidhormone,+is+sometimes+more+potent+than+T3"
There's references to papers where RT3 is more potent in some sitiuations that T3, and some of the known (at that time, year 2000) breakdowns of T4..including T4.
Then there's a great paper of the differing deiodinases,
http://findarticles.com/p/articles/mi_m0FDN/is_4_5/ai_65068470/?tag=content;col1
over 30 pages if you want to read it! Its written in 2000, so much has been discovered since (google on thryoid hormone deiodinases)... theres all the is it conjugates of thryoid hormones also..like sulfonation, nitration, hydroxylation, the thryoid amine etc ..which speed or slow down , change function etc Its a huge , mostly unknown ..and not able to be fully understood by me in my lifetime stuff, so just looking at RT3 and T3 is really over-simplistic to be meaningful , but I guess a start?
Here's some other abstracts ..just to get an idea
http://www.ncbi.nlm.nih.gov/pubmed/20051527
Maybe its best looked at like temperature. We get a fever in RESPONSE toi something. Its a life saving mechanism to aid our bodies, but sometimes we need to step in and reduce it. I look at RT3 the same way maybe and cortisol (both I thiink) could be viewed as coping responses to something going on. Yes we all have some Rt3 , we are supposed to have, and we all have a temperature as well. Its the level, and its a response.
end of edit.
Also growth hormone increases T3...and exercise (especially when fasting,say in the morning before you eat breakfast increases growth hormone), so one fairly easy way I'd hazard a guess of increasing T3 to RT3 ratio is to start exercising for a couple of hours each morning?..safe way too. (i think there are studies on that..or some people starting to think that way)
It's what humans used to do before the modern time..get up hunt/gather/milk the cows, farm etc ..then cook breakfast (after separating the milk/cream, baking the bread, fetching the egges etc). Not get up and eat straight away. People who get up and say go for a run or row etc in the morning usually stay lean and have high growth hormone, and probably don't have a high Rt3 unless there is something wrong with them like an illness...
just a thought, and something I think may be starting to catch on.
eating many times a day I suspect increases RT3, I think we are not really designed to do this if ou look at the native communities. Feasting occasionally was more the norm.
The growth hormone /T3 is in a study somewhere- the rest is just observation I've made over the years and guesswork, I could be wrong but its my personal belief.
http://thyroid-insulin.blog.co.uk/2006/08/30/growth_hormone_stimulates_conversion_of_~1081430/
link chosen as is on folate, homocysteine, growth hormone etc...
Hope this helps- my thoughts higher levels of cortisol , and higher RT3 is are coping reactions, usually just what we need , but they may imply something is stressing us in some way
Adding a SR T3 would be expected help the T3: RT3 ratio and may sometimes be of benefit (but its something like a last resort really), although I have myself personaly done it- out of desperation I guess
(scrip from a german trained GP...they study metabolism more over there than in Oz I think). As above shows there are other things to trial first that will change the ratio. Hopefully stepping down now...
