Niacin and the gut

[ruben]

I have had ME/CFS for many years since having had glandular fever. Of course I've naturally had the fatigue, generally unwell, migraines, but I think my most debilitating symptoms have been digestive problems, nausea and bloatedness. No gut pain. Tendency for constipation but then I had that before the ME/CFS anyway. I could cure the constipation though with fruit cubes and prune juice. Not having constipation though didn't make any difference to my general well being. A couple of months ago my nausea and bloatedness became REALLY bad and had been like that for a couple of months. I then read something about niacin and thought I'd try some. 100mg was dose I was taking each day. The effect was more or less immediate. Within a couple of days. Nausea basically gone. Appetite much improved. Able to enjoy snacking too between meals, whereas normally between meals I couldn't even enjoy something like a biscuit. I think I was gaining weight too. Anyway after 3 or 4 weeks the benefits seemed to wain. If I was taking then 100mg daily does anyone have any advice as to what other supplement(s) might enhance any benefits to the niacin. All suggestions much appreciated.

 

[Judee]

Members were talking in this thread about a doctor who has been working with Long Covid patients and having success with Niacin and co-factors. https://forums.phoenixrising.me/thr...-h-e-l-p-treatment.86184/page-16#post-2388795

@anne_likes_red posted a print screen of what he prescribes in post #303.

Maybe adding the co-factors would help. ??

Also @halcyon mentioned toxicity at higher doses on that same page.

Hope you can figure this out especially since it sounds like it was initially helpful for you.

 

[anne_likes_red]

I have had ME/CFS for many years since having had glandular fever. Of course I've naturally had the fatigue, generally unwell, migraines, but I think my most debilitating symptoms have been digestive problems, nausea and bloatedness. No gut pain. Tendency for constipation but then I had that before the ME/CFS anyway. I could cure the constipation though with fruit cubes and prune juice. Not having constipation though didn't make any difference to my general well being. A couple of months ago my nausea and bloatedness became REALLY bad and had been like that for a couple of months. I then read something about niacin and thought I'd try some. 100mg was dose I was taking each day. The effect was more or less immediate. Within a couple of days. Nausea basically gone. Appetite much improved. Able to enjoy snacking too between meals, whereas normally between meals I couldn't even enjoy something like a biscuit. I think I was gaining weight too. Anyway after 3 or 4 weeks the benefits seemed to wain. If I was taking then 100mg daily does anyone have any advice as to what other supplement(s) might enhance any benefits to the niacin. All suggestions much appreciated.

I watched this presentation from Chris Masterjohn and decided TMG and glycine might be wise - actually I was already using glycine along with NAC before bed.
Despite adding TMG I have to mention.....my acute positive response to Niacin has waned too. I'm still noticing benefits I think, but the POTS improvement has slipped. :/
Anyway here is CM's video, in case it's helpful...