I have had ME/CFS for many years since having had glandular fever. Of course I've naturally had the fatigue, generally unwell, migraines, but I think my most debilitating symptoms have been digestive problems, nausea and bloatedness. No gut pain. Tendency for constipation but then I had that before the ME/CFS anyway. I could cure the constipation though with fruit cubes and prune juice. Not having constipation though didn't make any difference to my general well being. A couple of months ago my nausea and bloatedness became REALLY bad and had been like that for a couple of months. I then read something about niacin and thought I'd try some. 100mg was dose I was taking each day. The effect was more or less immediate. Within a couple of days. Nausea basically gone. Appetite much improved. Able to enjoy snacking too between meals, whereas normally between meals I couldn't even enjoy something like a biscuit. I think I was gaining weight too. Anyway after 3 or 4 weeks the benefits seemed to wain. If I was taking then 100mg daily does anyone have any advice as to what other supplement(s) might enhance any benefits to the niacin. All suggestions much appreciated.