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Interesting you mentioned Mianserin. My mother had severe intractable pain in her left leg which almost totally disabled her.
She was given a combination of painkillers and Mianserin. The first night she took them she wakened up the next morning lying on the bathroom floor where she had swallowed them
She then took just one tablet lying in bed. Very quickly, her pain went after months of trying out treatments. The consultant said she had had an infection in the nerve causing inflammation which the mianserin got rid of that. (No one ever digested it was psychological or depression)
Mithriel
I used Mirtazapine in the past myself, it didnt do anything in terms of altering my mood but it was one hell of an effective sleep med, worked on me in the same way you described, almost instant. Knocks the socks off of things like Zopiclone. However, there are still some potentially dangerous properties i have since discovered with it too so noone should take this as an endorsement .