'New' antiinflammatory antioxidant drug on the market

[melihtas]

My sublingual Galavits arrived 3 days ago. This morning I took the third dose. It stopped my ibs diarrhea after second day. For the first time in last ten years, I didn't take Loperamide to reduce bowel movements since two days ago.

I haven't felt any difference regarding other ME symptoms but it is too early. Average response time for Rituximab was 3 months if I remember correctly. I am hopeful.

The last two days prior to starting Galavit was very exhausting for me including a 10 hour coach travel. I was in PEM when I started Galavit. I am still in PEM but it is slightly milder than the previous ones. Galavit might be alleviating symptoms but it is too early to draw conclusions.

 

[melihtas]

Two weeks on Galavit:

My ibs diarrhea came back after 4 good days although it is different from before galavit (color and shape).

My sleep is improved for the last week. Before galavit, I was taking Zaditen tablets (Ketotifen Fumarate) to be able to sleep. Zaditen is an antihistamine and mast cell stabilizer. I started taking zaditen 2 years ago after reading about mast cell issues and ME. It didn't help with any of my symptoms but it made me sleepy as a side effect and I started taking it 2 hours before bed to take advantage of this side effect. Without zaditen I wasn't able to sleep till 3-4 a.m. and then only poor sleep for a few hours. With zaditen I easily fell asleep, I used to wake up 3-4 times a night with the need to urinate and drink some water but my sleep was deep beetween those wake ups and I wasn't feeling sleepy during the day.

For the last one week while I was on galavit I stopped taking zaditen. Now, it takes 10-20 minutes to fall asleep and I wake up only once a night. I also have much less night sweats although it is summer and hotter.

No improvements in other symptoms yet.

 

[melihtas]

Results of my two month trial with Galavit:

In short, no improvements at all, no side effects either.

Initial slight improvements which I reported after first week had probably nothing to do with Galavit. It was the begining of summer and I managed to go to beach for a few days. Spending time in sea water always alleviates my ME symptoms for a while.

After the first five days, I took Galavit once in every three days. On the days I took Galavit I had a mild weird feeling in my head. It was not too disturbing and I think it was a sign of it was doing its job.

Why didn't it work?

Maybe I didn't have any inflamation and microglial activation in my brain or - and more likely - I have microglial activation and inflamation but it is not the cause but the result of ME. See this thread about microglial activation is not necessarily a bad thing.

Drs. Fluge and Mella also stopped Enbrel (TNFa inhibitor) study because it was not working. See this thread.

Rituximab therapy is the most effective treatment for ME at the moment but I cannot afford it. I will try the drugs which increase the endothelial NO synthase. The below picture is from Rituximab funding application. Drs. Fluge and Mella think that autoantibodies disturb NO syntesis in endothelial cells. See this thread.