I have been looking into things that could potentially regulate Nrf2 activity (see why) and came across this 'novel' drug. It has been used in Russia for decades, now it seems it has been repackaged and in search of new markets.
The mechanisms of action sound 'too good to be true' I haven't seen it discussed or suggested as having potential for ME. Any docs use it? (on the other hand it is not clear if it is available at all, or would be, outside Eastern and Central Europe?)
http://www.bachpharma.com/origins.php
The mechanisms of action sound 'too good to be true' I haven't seen it discussed or suggested as having potential for ME. Any docs use it? (on the other hand it is not clear if it is available at all, or would be, outside Eastern and Central Europe?)
http://www.bachpharma.com/origins.php
- Has the ability to enter cells of the central nervous system and immune system, thereby delivering therapeutic results to the gut, thymus, spleen and blood
- Has the ability to cross the blood-brain barrier and retinal-brain barrier
- Anti-oxidant and anti-inflammatory properties as it scavenges free radicals
Platform Drug Mechanism of Action Bach’s researchers have discovered the Mechanism of Action of its drug platform Monosodium Luminol GVT®.
Data from published studies shows that GVT®:
Mechanism of Action Platform Drug Effects Monosodium Luminol GVT® has powerful effects on multiple pathways and networks:
- Regulates the activity of macrophages and synthesis of pro-inflammatory (IL-1, IL-6, TNF-alpha) and anti-inflammatory (IL-10) cytokines
- Increases the level of immunoglobulins (IgM, IgA) in their failure, normalizes affinity immunoglobulin
- Regulates the proliferative activity of subpopulations of T lymphocytes (T helper, T-killers)
- Regulates the cytotoxic activity of NK cells
- Has a stimulating effect on the phagocytic activity of neutrophils during its initial deficit
- Regulates the synthesis of interferon alpha and gamma
- Has antioxidant effect
- Regulates the repair of damaged tissue
- Regulates Nrf2 with increased production of glutathione (GSH) and thioredoxin
- Restores mitochondrial membrane potential when mitochondria is under stress, and also prevents mitochondrial-induced cell death
- Relatively non-toxic, well absorbed, can be taken orally, rapidly excreted, can get into the brain by passing through the blood brain barrier
- Prevents oxidative stress, both by scavenging free radicals and by regulating Nrf2 with increased production of glutathione (GSH) and thioredoxin
- Reacts with peroxinitrite thereby preventing protein nitration and oxidation in microglia and preventing microglia-induced neuronal damage
- An iron and other heavy metal chelator and thereby prevents iron-catalyzed oxidative damage
- Decreases intracellular reactive oxygen species (ROS) levels in astrocytes and other cell types under various stress conditions
Drug Effects Platform Drug PK & Advantages
The Monosodium Luminol GVT® drug platform is available for use in many methods of application, has a proven safety record in humans, and is beneficial for use in adjunctive therapeutic treatments.