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A couple of weeks ago I started taking methylfolate 1000 mcg, I was on it for two weeks and during that time I started getting depressed, anxious, confused, etc. I clearly didn't do enough research and found out that taking methylfolate alone can cause methyl trapping. I then stopped the methylfolate, waited a couple of days, then started taking a B-complex that contains both methylfolate (800 mcg) and methylcobalamin (200 mcg), it also has B1 (62 mg), B2 (50 mg), B6 (24 mg) and niacin (100 mg).
At first, this completely reversed my symptoms that I got from taking the methylfolate alone, but quickly afterwards I started getting neuropathy type of symptoms, my arms and legs feel like they're burning. My eyes burn and my vision is getting blurry, my fingertips have gotten pruney too.
Did I induce a methyl trap/overmethylation?
I'm Heterozygous for MTR and MTRR, and Homozygous for CBS (C699T) and COMT (rs4680) My MTHFR is fine.
My blood levels: Serum B12 was high, homocysteine was normal-high, and folate was normal-low.
I'm going to try a very low dose of sublingual methylcobalamin (125 mcg), to see if that can help. If not, then I don't know what to do.
At first, this completely reversed my symptoms that I got from taking the methylfolate alone, but quickly afterwards I started getting neuropathy type of symptoms, my arms and legs feel like they're burning. My eyes burn and my vision is getting blurry, my fingertips have gotten pruney too.
Did I induce a methyl trap/overmethylation?
I'm Heterozygous for MTR and MTRR, and Homozygous for CBS (C699T) and COMT (rs4680) My MTHFR is fine.
My blood levels: Serum B12 was high, homocysteine was normal-high, and folate was normal-low.
I'm going to try a very low dose of sublingual methylcobalamin (125 mcg), to see if that can help. If not, then I don't know what to do.
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