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Hi everyone,
Just want to say I'm happy I stumbled upon this site. someone gave me a link to the biofilm thread while I was trying to fix my gut. thanks for everyone for their own research and contribution. This site has been very helpful.
I need help interpreting my Health Diagnostics and Research Institute (HDRI) methylation test results, 23andme, common methylation and detox SNPs from geneticgenic. And advice on what treatment I should follow? Starting out, I've been using Fredd's b12 protocol along with Rich's simplified protocol. Looking at my SNPs on geneticgenie and a few SNPs related to muscle pain on 23andme with reference to Snpedia, I don't see many problems with my main detoxification and methylation SNPs other than MAO-A and COMT rs4633, rs 4680 for fibromylgia/pain. +/- MTHFR c677t, ignoring the +/+CBS360A.
Overall, my SNPs don't suggest any potential issues that I know of. But my methylation tests shows I have nutrient/cofactors deficiencies across the board and slowed methylation and/or block.
For methylation and supplementation for overall health;
Should I use Rich's treatment along with most of Fredd's recommendation of essential and additional co factors? I should be supplementing these anyways to replenish loss vitamins and minerals from being sick for so long.
For methylation supplementation and other reasons; I'm on liq. hydroxyb12 (peroxynitrite), high P5p/B6, liq. adenob12/methylb12, folinic acid/L-MTHF, metafolin, phospholipids/serine complex, tmg and the rest of the all important b vitamins..b1, b2 fmn and b2, biotin and niacin/b3 if needed. Should I supplement with SAMe directly or take precursors? and phosphylcholine to lessen the need for it. A b complex?
What dosages for b12, folate b6, and others? I've tolerated everything so far. Should I increase it or assume everything is fine. Do pulsing? I've also stopped liposomal GSH a while ago. I've never taken GSH precursors like NAC even when it shows on an OAT..
This is becoming too much to supplement and overwhelming.
Also trying to find a mutivitamin and high ORAC/polyphenols powder with antioxidants to go with my morning probiotics/prebiotics shake. One that I can tolerate (no enzymes, antimicrobial herbs, lacto. acidophilus or histamine). Just using a mineral liquid complex and acai, aronia powders.
Anyways, here are my symptoms, health issues and concerns:
Severe autoimmune skin disease, equally severe arthritis; think handicapped, gout/high uric acid, swollen/stiff joints in neck, fingers, knees, feet, I have ankylosing spondylitis and my curvature makes it difficult to walk straight, insomnia, little fatigue, muscle soreness especially in my arm/shoulders, IBS-C, strong appetite for fat/carbs, sensitives, very anemic, low iron/Iron Bind.Cap.(TIBC), cold sensitivites, cold hands/feet, underweight, anxiety, depression at times, feeling of empitness, easily frustrated/upset and worrying (anxiety). Just to name a few. I used to have more fatigue, get tired easily and brain fog.
sidenote; I'm unsure of what happened to me in the past few days. I had problems with my kidney and lower back which was preventing me from bending. I already had terrible posture. Could it be likely have had calcium oxalates/kidney stones? Only thing I added was adding higher doses of b6 prior. twinlab's acetyl-carnithine. I alleviated the pain considerably with B6, B's supplementation/Mg/Mg citrate, arginine, taurine, diet and drinking something acidic frequently.
HDRI
geneticgenie
23andme's raw data:
SUOX rs705703 56391486 C or T C / C
SUOX i5000977 56397916 A or C A / A
SUOX i6028286 56397941 C or T C / C
SUOX i5000976 56398711 A or G A / A
mthfr-support; no comt snps that i see could be a problem other than what i mentioned earlier.
I did Promethease as well and see some interesting analysis.
first thing that shows up,
rs2231142(A;A)
causes gout
hmm..
rs6265(A;A)
introversion; depression resistant; impaired motor skills learning
balding runs in the family
gs122
thyroid cancer
rs2145418(G;G)
Those are some of lowest frequency and more relevant snps if i understand things correctly.
Are there any other SNPs that I should be looking at for other health issues?
I know these DNA SNPs and results don't necessarily predispose one to a disease; I'm just interested in them since people have done a lot of research in this field. How significant of a causative agent are SNPs to someone developing a illness or is it more of a deeper issue like stress, diet, nutritional imbalance, overgrowth or infection, environment, aftermath of overgrowth and its byproducts leading to a block on one or multiple metabolic pathways causing one's immune system, systems/organs to have to detoxify too much and causing slowed pathway or block. Ex: oxalate dumping thread and info for example, peroxynitirate, ammonia, etc.
Or an accumulation of it all.
Studying the DNA genome/epigenetics is something I am interested in so long it is highly relevant to me and it yields consistent results.
Regarding my OAT, I am confused as to why my Methylmalonate is low if I have the methylation markers that I have with HDRI. Rich and a few others state how high MMA is indicative of lower functional b12. It also states it on the Genova's organic acids interpretation pdf. Is this from dysbiosis and the bacteria making b12?
Anyways, I am relatively new at analyzing SNPs, study of epigenetics, interpreting tests and nutrigenomics. I am still working on restoring my gut/detoxing/keystones with fermented foods, pre/probiotics, eating a diverse, low oxalate diet. More antioxidants, fodmaps, homemade fermented foods, water kefir. Hopefully more kraut soon.
Heavy metals, hair/blood/urine:
Ca, copper, mg high. Avoiding vit. c because of copper/oxalate.
harmful metals:
Silver is very high. Not sure how, haven't looked into this.
CDSA
How much of focus should I put on the Kreb's cycle after having dysbiosis/yeast/poor health?
And how would one go about reducing uric acid/salvaging purines.
thanks everyone
Just want to say I'm happy I stumbled upon this site. someone gave me a link to the biofilm thread while I was trying to fix my gut. thanks for everyone for their own research and contribution. This site has been very helpful.
I need help interpreting my Health Diagnostics and Research Institute (HDRI) methylation test results, 23andme, common methylation and detox SNPs from geneticgenic. And advice on what treatment I should follow? Starting out, I've been using Fredd's b12 protocol along with Rich's simplified protocol. Looking at my SNPs on geneticgenie and a few SNPs related to muscle pain on 23andme with reference to Snpedia, I don't see many problems with my main detoxification and methylation SNPs other than MAO-A and COMT rs4633, rs 4680 for fibromylgia/pain. +/- MTHFR c677t, ignoring the +/+CBS360A.
Overall, my SNPs don't suggest any potential issues that I know of. But my methylation tests shows I have nutrient/cofactors deficiencies across the board and slowed methylation and/or block.
For methylation and supplementation for overall health;
Should I use Rich's treatment along with most of Fredd's recommendation of essential and additional co factors? I should be supplementing these anyways to replenish loss vitamins and minerals from being sick for so long.
For methylation supplementation and other reasons; I'm on liq. hydroxyb12 (peroxynitrite), high P5p/B6, liq. adenob12/methylb12, folinic acid/L-MTHF, metafolin, phospholipids/serine complex, tmg and the rest of the all important b vitamins..b1, b2 fmn and b2, biotin and niacin/b3 if needed. Should I supplement with SAMe directly or take precursors? and phosphylcholine to lessen the need for it. A b complex?
What dosages for b12, folate b6, and others? I've tolerated everything so far. Should I increase it or assume everything is fine. Do pulsing? I've also stopped liposomal GSH a while ago. I've never taken GSH precursors like NAC even when it shows on an OAT..
This is becoming too much to supplement and overwhelming.
Also trying to find a mutivitamin and high ORAC/polyphenols powder with antioxidants to go with my morning probiotics/prebiotics shake. One that I can tolerate (no enzymes, antimicrobial herbs, lacto. acidophilus or histamine). Just using a mineral liquid complex and acai, aronia powders.
Anyways, here are my symptoms, health issues and concerns:
Severe autoimmune skin disease, equally severe arthritis; think handicapped, gout/high uric acid, swollen/stiff joints in neck, fingers, knees, feet, I have ankylosing spondylitis and my curvature makes it difficult to walk straight, insomnia, little fatigue, muscle soreness especially in my arm/shoulders, IBS-C, strong appetite for fat/carbs, sensitives, very anemic, low iron/Iron Bind.Cap.(TIBC), cold sensitivites, cold hands/feet, underweight, anxiety, depression at times, feeling of empitness, easily frustrated/upset and worrying (anxiety). Just to name a few. I used to have more fatigue, get tired easily and brain fog.
sidenote; I'm unsure of what happened to me in the past few days. I had problems with my kidney and lower back which was preventing me from bending. I already had terrible posture. Could it be likely have had calcium oxalates/kidney stones? Only thing I added was adding higher doses of b6 prior. twinlab's acetyl-carnithine. I alleviated the pain considerably with B6, B's supplementation/Mg/Mg citrate, arginine, taurine, diet and drinking something acidic frequently.
HDRI
geneticgenie
23andme's raw data:
SUOX rs705703 56391486 C or T C / C
SUOX i5000977 56397916 A or C A / A
SUOX i6028286 56397941 C or T C / C
SUOX i5000976 56398711 A or G A / A
mthfr-support; no comt snps that i see could be a problem other than what i mentioned earlier.
I did Promethease as well and see some interesting analysis.
first thing that shows up,
rs2231142(A;A)
causes gout
hmm..
rs6265(A;A)
introversion; depression resistant; impaired motor skills learning
balding runs in the family
gs122
thyroid cancer
rs2145418(G;G)
Those are some of lowest frequency and more relevant snps if i understand things correctly.
Are there any other SNPs that I should be looking at for other health issues?
I know these DNA SNPs and results don't necessarily predispose one to a disease; I'm just interested in them since people have done a lot of research in this field. How significant of a causative agent are SNPs to someone developing a illness or is it more of a deeper issue like stress, diet, nutritional imbalance, overgrowth or infection, environment, aftermath of overgrowth and its byproducts leading to a block on one or multiple metabolic pathways causing one's immune system, systems/organs to have to detoxify too much and causing slowed pathway or block. Ex: oxalate dumping thread and info for example, peroxynitirate, ammonia, etc.
Or an accumulation of it all.
Studying the DNA genome/epigenetics is something I am interested in so long it is highly relevant to me and it yields consistent results.
Regarding my OAT, I am confused as to why my Methylmalonate is low if I have the methylation markers that I have with HDRI. Rich and a few others state how high MMA is indicative of lower functional b12. It also states it on the Genova's organic acids interpretation pdf. Is this from dysbiosis and the bacteria making b12?
Anyways, I am relatively new at analyzing SNPs, study of epigenetics, interpreting tests and nutrigenomics. I am still working on restoring my gut/detoxing/keystones with fermented foods, pre/probiotics, eating a diverse, low oxalate diet. More antioxidants, fodmaps, homemade fermented foods, water kefir. Hopefully more kraut soon.
Heavy metals, hair/blood/urine:
Ca, copper, mg high. Avoiding vit. c because of copper/oxalate.
harmful metals:
Silver is very high. Not sure how, haven't looked into this.
CDSA
How much of focus should I put on the Kreb's cycle after having dysbiosis/yeast/poor health?
And how would one go about reducing uric acid/salvaging purines.
thanks everyone
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