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Nasal Cells and Mitochondria


Senior Member

Summary:Exposure to air particulate matter impairs the metabolism of olfactory mucosal cells, according to a recent study. The results can contribute to a better understanding of how air pollutants may harm brain health, as the olfactory mucosa can act as a key pathway to the brain.

I noticed this: "The researchers also identified the mitochondria-targeted NPTX1 gene, which has been shown previously to be associated with brain disorders, as a key driver of mitochondrial dysfunction upon particulate matter exposure." Following that to wikigenes, I found:
  • Sema-3A/NP-1 interaction down-modulated T cell activation since addition of Sema-3A in DC/T cell cocultures dramatically inhibited allogeneic T cell proliferation [20].
I'm not sure what that means, but anything involving the immune system might be a link to ME. I can imagine ME making people more sensitive to airborne pollutants via this mechanism, or possibly making some PWME more vulnerable to airborne viruses.