Hence the term "myalgic encephalomyelitis" is clinically inaccurate and inadequate
Hello. Well that's one view point certainly, and it would be easy to say that ME doesn't involve neuroinflammation in a classical sense I agree (gross inflammation along the lines of bacterial infiltration),
until you hear of the very latest research, American of course, that is suggestive of a subtle version of an ME -itis, and one that may be transient.
Naturally, doctors aren't aware of this up to date knowledge, and if they were, can't believe it, so dismiss the idea of ME actually being present in anyone diagnosed with ME or CFS, by sticking to the classical description of an inflamed brain. (In the UK, an ME post mortem study(s) did show inflamed spinal cord tissue - ganglionitis and corpora amylacea (waste product of dead neurons if I remember correctly), which is somewhat alarming but perhaps inevitable in a disease that affects your brain so adversely and so young, and gives teens the short term memory of a 70yr old.
Cort Johnson did a write up on Dr Anthony Komaroff's thoughts on 'ME itis' online called:
Neuroinflammation: Putting the ‘itis’ back into Myalgic Encephalomyelitis – Back to the Future For Chronic Fatigue Syndrome?
And here are some quotes from Dr Anthony Komaroff, saying an ME- 'itis' in CFS, is indeed possible.
“Our results provide evidence of neuroinflammation in CFS/ME patients, as well as evidence of the possible contribution of neuroinflammation to the pathophysiology of CFS/ME.“
''“There is, and you’ve heard it repeatedly in the last three days, a theory that CFS might reflect an ongoing activation of immune cells in the brain, not in the periphery, but in the brain”.
“Yes. If it were confirmed by multiple other investigators it would, for me, say that there is a low-grade, chronic encephalitis in these patients, that the image we clinicians have of encephalitis as an acute and often dramatic clinical presentation that can even be fatal has – may have – blinded us to the possibility that there may be an entity of long-lasting – many years long – cyclic, chronic, neuro-inflammation and that that underlies the symptoms of this illness”, commenting that it was “entirely plausible and these data are consistent with it”.
Source:
http://www.cortjohnson.org/blog/201...yelitis-back-future-chronic-fatigue-syndrome/
Also another American researcher, Jarred Younger is proposing measuring
brain temperature in CFS patients. . This might be a novel way to detect low level neuro inflammation in CFS, where a conventional MRI fails to:
You can see the video of this in a discussion, here, at 9.00 elapsed:
Thanks.