Continuing on the very nice discussions and debate we've been having as to whether ME/CFS is more infectious or autoimmune I want to throw out this controversial opinion based on my own treatment results and in light of the rituximab findings.
Let me be clear I totally believe that there is some neuroinflammation in ME/CFS and it's been proven (Shungu et al, Nakatomi et al). I just think that it's a secondary effect to peripheral immune activation and this is also seen in a number of autoimmune diseases.
I used to think that the root cause of ME/CFS could be neuroinflammation so i decided very early on in my treatment protocol to do aggressive treatment to combat this with the following combo:
Valcyte*
Famvir
Immunovir
Doxycycline*
LDN*
Memantine*
Celecoxib*
Gabapentin*
Clonidine*
Tiagabine*
A bunch of anti-inflammatory supplements (curcumin, resveratrol, alpha lipoic acid, etc)
The starred (*) drugs have been shown inhibit neuroinflammation.
Even with long-term aggressive treatment using the above potent combo of anti-neuroinflammatory drugs it has not improved the core symptoms of this disease.
I know there are other anti-neuroinflammatory drugs such as Ibudilast (which i cannot get and would try if I could) but honestly if the root cause was neuroinflammation then the above combo should've worked after taking it more than 1.5 years?!? I'm pretty sure I don't have any neuroinflammation going on anymore but nothing has changed.
I just feel in my body that there is something else going on that is driving this disease.
Could it be that this combo isn't working because I've been working full-time since I got sick and am in a pretty much constant state of PEM and crashing often?
Let me be clear I totally believe that there is some neuroinflammation in ME/CFS and it's been proven (Shungu et al, Nakatomi et al). I just think that it's a secondary effect to peripheral immune activation and this is also seen in a number of autoimmune diseases.
I used to think that the root cause of ME/CFS could be neuroinflammation so i decided very early on in my treatment protocol to do aggressive treatment to combat this with the following combo:
Valcyte*
Famvir
Immunovir
Doxycycline*
LDN*
Memantine*
Celecoxib*
Gabapentin*
Clonidine*
Tiagabine*
A bunch of anti-inflammatory supplements (curcumin, resveratrol, alpha lipoic acid, etc)
The starred (*) drugs have been shown inhibit neuroinflammation.
Even with long-term aggressive treatment using the above potent combo of anti-neuroinflammatory drugs it has not improved the core symptoms of this disease.
I know there are other anti-neuroinflammatory drugs such as Ibudilast (which i cannot get and would try if I could) but honestly if the root cause was neuroinflammation then the above combo should've worked after taking it more than 1.5 years?!? I'm pretty sure I don't have any neuroinflammation going on anymore but nothing has changed.
I just feel in my body that there is something else going on that is driving this disease.
Could it be that this combo isn't working because I've been working full-time since I got sick and am in a pretty much constant state of PEM and crashing often?
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