MTHFR & COMT

[Kreiss]

I did some gene lab tests and found out I am homozygous MTHFR - C677T and homozygous COMT - rs4680 Val. The explanation says higher COMT activity and parallel reduction in frontal lobe dopamine. From my understanding this means my body breaks down dopamine faster than normal. Every time I try to take the l-methylfolate to help with the MTHFR mutation, I get anxious. What I don't understand is if I am COMT - rs4680 val, why do I get the anxiety, if my body breaks down dopamine faster than normal.

What can I do to be able to take the l-methylfolate without getting the anxiety.

Thank you for your help

 

[zzz0r]

No thats not it. COMT++ is a downregulation meaning that dopamine is broken down slower than normal by the receptors. So large ammounts of dopamine are concentrated in the brain

 

[Kreiss]

Thank you for your response. It can go either way depending if you are COMT MET or COMT VAL. In this link it explains how the COMT val/val (warriors) affects dopamine. It states people with this allele break down dopamine faster than normal.

http://www.snpedia.com/index.php/Rs4680

It is the same explanation I got from the results report at Gonomind (where I had the lab tests done): "Associated with higher COMT activity and parallel reduction in frontal lope dopamine and working memory."

It seems everytime I try to help the methylation pathway, I get anxious. I took trimethylglycine (TMG), which is a methyl donor, and I got anxiety too.

What can I do to be able to take the l-methylfolate or TMG without getting the anxiety.

 

[zzz0r]

Kreiss is the first time I hear about this hypothesis. I am COMT V158M++ and COMT H62H ++. My symptoms are those of high dopamine that means anxiety in general that increases with methyldonors. Also I have that kind of character that always want to achieve more staff and be competitive, also explained by increased levels of dopamine. I can not either tolerate methylfolate. Btw do you get any other symptoms except anxiety when taking methylfolate?

 

[Kreiss]

so are you rs4680 val/met ? I am rs4680 val/val. The only symptom I get when I try methyl donors is anxity. It is not only with methylfolate, but with any methyl donor. I started taking trimethylglycine (TMG) last Wednesday, and my anxiety worsen by Friday. Had to stop taking it. I wonder what is the cause for this. I read in other threats it is not necessary due to COMT mutation. But so, how can one discover what is the reason ?

http://forums.phoenixrising.me/index.php?threads/comt-and-methylfolate.21850/

Can anyone please shine some light to this. or what to test to find out why this is happening.

Thank you very much for your help.

 

[musicchick581]

What are your sulfate levels? Aluminum or heavy metals?

 

[musicchick581]

What if you are COMT A/G, are you both warrior and worrier???

 

[Kreiss]

No, I am not COMT A/G. from the genomind lab test, I am COMT Val/Val, which means I am COMT VAL 158 GG. I have not tested sulfate levels, aluminum or heavy metals. are these tests done through hair or blood ? Could that be the reason why I get anxious when I take any methyl donor.

Thank you.

 

[Kreiss]

I finally got the results from 23andme:

COMT V158M rs4680 GG -/-
VDR Taq rs731236 AA +/+
MAO A R297R rs6323 GT +/-
MTHFR C677T rs1801133 AA +/+
MTRR A66G rs1801394 AG +/-
MTRR K350A rs162036 AG +/-
MTRR A664A rs1802059 AG +/-

I went to see my naturopatic Doctor today, and She told me my symptoms do not match with the results from the test, meaning people who are COMT V158M rs4680 (GG) (-/-) should tolerate the methyl donors well. She does not understand why I get anxious when I take a methyl donor. Do you have any ideas why this could be happening ?

BTW, I take pristiq - 150 mg.

Thanks a lot for your help.

 

[Valentijn]

I went to see my naturopatic Doctor today, and She told me my symptoms do not match with the results from the test, meaning people who are COMT V158M rs4680 (GG) (-/-) should tolerate the methyl donors well. She does not understand why I get anxious when I take a methyl donor. Do you have any ideas why this could be happening ?

There are other COMT, VDR, and MAO variations which can have an impact, not just the few listed by Yasko and Genetic Genie.

http://forums.phoenixrising.me/index.php?threads/interesting-vdr-variations.24480/
http://forums.phoenixrising.me/index.php?threads/interesting-comt-variations.24672/

I haven't looked for MAO variations.

 

[musicchick581]

No, I am not COMT A/G. from the genomind lab test, I am COMT Val/Val, which means I am COMT VAL 158 GG. I have not tested sulfate levels, aluminum or heavy metals. are these tests done through hair or blood ? Could that be the reason why I get anxious when I take any methyl donor.

Thank you.

Any idea how that translates to 23 and me?

 

[TSoule]

Kreiss is the first time I hear about this hypothesis. I am COMT V158M++ and COMT H62H ++. My symptoms are those of high dopamine that means anxiety in general that increases with methyldonors. Also I have that kind of character that always want to achieve more staff and be competitive, also explained by increased levels of dopamine. I can not either tolerate methylfolate. Btw do you get any other symptoms except anxiety when taking methylfolate?

Hi (new here)--just got my 23& Me results and am also V158M++ and COMT H62H--I have looked all over the internet and according to Yasko she recommends "MethylMate A Caps," "MethylMate B Caps" and B-12 (sublingual hydroxy-cobalamine). I am a little nervous about trying anything with Folate as I have not had good luck in the past either--but really want to "fix" this issue if at all possible. What types of folate have you tried, and any with success? Thanks very much--take care, Tammi