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Hi @Leon ;
I've been all over the place trying to figure this out...
Some research claims that intracellular calcium correlates to serum calcium, some claim it doesn't.
I think a Comprehensive Metabolic Panel would be a good measure for calcium, and other electrolytes.
Metametrix, in their analysis, states that high intracellular calcium indicates the cell membrane is compromised. They recommend magnesium, antioxidants, and omega 3 fatty acids to rectify this.
http://www.metametrix.com/files/test-menu/interpretive-guides/Elements-IG.pdf
I see you've had problems with magnesium chloride. Have you tried other compounds, such as mg. glycinate, taurate, citrate, threonate, gluconate, etc.? ( personally, I use mg. chloride trandermally.)
I read on another thread that you get cramps from magnesium, but that sodium relieves them. Low sodium can cause cramps too.
If you are intolerant of many types of magnesium, it may be a good idea to test serum or RBC mg. ( It could be high.)
That's useful; thanks, Crux. Salt does seem to work like a charm for my muscle twitches. With lots of people talking about magnesium highlighting a potassium deficiency - which can also cause cramps - it gets rather confusing. I'm going to try magnesium glycinate, perhaps.
As for compromised cell membranes, this would make sense. In the Methylation Panel I have high serum folic acid, which he also suggests might be related to compromised membranes.