The problem is that these deficiencies cause inflammation and tons of symptoms, potentially hundreds of symptoms anyway. MeCbl, AdoCbl, L-methylfolate and the individually best l-carnitine, any of which in deficiency shuts down all 4 over time and in doing so stops the ability to heal. Turning on healing then causes a multitude of contradictory seeming symptoms which amount to refeeding syndrome. As the B12 and folate starts up there is a bigger demand for nutrients than a persons body may have required in 30 years and hence the body can't supply the suddenly needed nutrients. So when I started I got increased low folate symptoms which I had all my life. Then when I started 400mcg of Metafolin it caused the most horrendous folate deficiency symptoms I have ever had with maybe one or 2 of 8 or so compartments healing and the other 6 or7 in worse folate deficiency, with a vengence. Then each time I increased l-methylfolate a few symptoms started improving and most got even worse as did low potassium. Then I added l-carnitine and suddenly had tons of energy and even more intense folate deficiency symnptpoms but fewer of them. At 4 mgs of Metafolin a day things were getting overall better, fewer different symptoms but still very intense. With each 50% increase there was some improvement. At 12mg I had days when all but 3 or 4 symptoms were very reduced. At about 18 mgs daily it began to be very few symptoms but they kept coming back. At 24mgs I had the symptpoms for about 5 days out of each 2 weeks and an extra doses got rid of them and going back to 24mg s they came back. At 28.8mg/day there were none coming back any more. I am folate deficiency symptoms free. However there were serious "methylation problem" symptoms getting worse quickly including SACD type demyelination which turned out to be copper deficiency, and then boron and manganese and molybdenum in a vary neat demonstration of refeeding syndrome deficiencies, each one corrected exposing the next layer of fewer symptoms.
I know of no way to heal without turning on cell building which can't help but cause refeeding syndrome, which is what almost everybody here is struggling with. It seems anti intuitive that fixing one deficiency just brings another to the forefront. Recognizing that allowed me to heal. The cost has been high. However, how many people do you know that are alive 23 or 24 years after congestive heart failure diagnosis? I also no longer have FMS, CFS, MCS, asthma, seasonal allergies, IBS, daily vomiting, acid regurgitation at night and so on. my kidneys have been improving since I reached 22mg or so of methylfolate. WIth my recent diagnosis of CblC disease, adult onset, it is clear that I had excess MMA and Hcy causing multi organ failure and widespread tissue breakdown. It causes (or results in) low cellular folate. which amounts to methyltrap. All these things are caused by the deadlocks in the methylation-ATP cycles. Even just folate polymorphisms can cause the deadlocks. It doesn't need anything as exotic as I have. Once the deficiencies are corrected its like people expect the struggle to be over. It isn't. The real struggle is just starting, refeeding syndrome. How much of what nutrients are needed to produce 50 pounds of new meat and to heal the rest of the body? The answer is more nutrients than your body has had to deliver of almost everything than it has had to deliver since the physical breakdown started. It can take a long time to starve to death from some vitamin deficiencies, one cell failure at a time .On the other hand scurvy and pellagra and beriberi are relatively fast which made them easy to recognize. With wholesale starvation, like concentration camps in WW2, ordinary food caused refeeding syndrome because everything was deficient.
With this kind of situation one has to start with the deficiencies that cause most of the symptoms. The deadlock quartet affects hundreds of poor methylation symptoms. In the presence of AdoCbl, MeCbl and L-carnitine, partial folate deficiency causes from dozens of symptoms to only one or two as one gets close to sufficiency. Then copper deficiency hits maybe 8 or 10 items with some of them HARD hits. Born hits only a couple of noticeable symptoms, and manganese and molybdenum each a couple of noticeable symptoms. Other people will hit things in different orders but the catch here is that each one has a smaller and smaller subsets of symptoms that look like same old with perhaps barely noticeable differences. So one deficiency might cause thin nails and hair whereas another causes brittle nails and hair. A person not paying close attention doesn't have a chance. One important thing is that as far as I can tell when one is successfully supplying the current "most limiting nutrient" the difference is noticeable in from less than an hour to as much as a one to two days with a change of symptoms patterns from day 3 or 4 onward. Also, except for excess of B1, B2, B3 and inositol causing increased low potassium and/or folate, an increase in potassium and/or methylfolate need is a real flag of something happening. So for me MeCbl cause a need for about 400-600 mg of potassium. Methylfolate caused a 1200 mg increased need. L-carnitine caused about an increase of 400-800mg of potassium, copper increased potassium need by 400mg, of boron, manganese and molybdenum increased potassium need by 200mg or so all together, each on the respective 3rd or 4th day after starting. I'm needing the most potassium now that I have ever needed except by excess b1, b2, b3 and inositol. As things complete some healing potassium need comes down a bit.
I don't know of any other method that works. For me it was a race with death or irreparable damage. I don't know of any other hypothesis that works. I had a terrible explosion and spreading from external to internal candida after an antibiotic from a dental infection threw things out of balance. The Augmentin for 10 days and/or Diflucan for a month appears to have caused liver damage, or something did and those are most likely cause, so now I'm having to deal with that. Not a single thing that I responded to, not the B12, not folate, not copper or anything came in "low", that is below bottom of range. Some were lower end of range. But if I had relied on "the usual" test results to show what was low, making my body break down, there was nothing. It's not easy. There is no magic formula. Most hypotheses turn out not to work. So one makes ones choices but can change them every few days. The correct ones generally give fast responses. The only one that I failed miserably on was glutathione but it taught me all about methyltrap, so now I can recognize it before it causes real damage. When I started having demyelination damage from the copper deficiency I was into the doctors and doing tests in a couple days and started copper the next day on theory. Within 4 hours I felt cessation of damage and in a day I felt it more, but painstakingly slow, as the references said. However, the other 3 minerals each have increased the rate of improvement very slightly, started the three at 1 a day and felt the effect of each and on the 3rd-4th day potassium need went up 200mg. I hope this helps you in figuring out what you need to do. Finding the the most limiting factors will make most everything else work better, so much better that other things become the most limit factors. Good luck.