It seems unlikely, to me, that a CVB infection could be the initial trigger to everyone's me/cfs. From my understanding there are a wide variety of infections that trigger me/cfs. For me, and others, it was obviously an ebv (and resulting mono) infection that was the initial trigger.
Yes agreed, but I think enterovirus may well be responsible for a good 50% of ME/CFS cases.
If you look at
Dr John Chia's assessment of the likely cause of ME/CFS in 200 consecutive patients, active enterovirus infection comes up in 55% of the patients. So although other pathogens (and non-infectious triggers such as vaccination) may potentially be causes of ME/CFS or ME/CFS-like symptoms, enteroviruses such as coxsackievirus B and echovirus are probably responsible for a good 50% of the cases.
It possible that different pathogens have different methods of causing ME/CFS. If we assume that ME/CFS is caused by the sort of energy metabolism blockages found in the Myhill, Booth and McLaren-Howard Studies, and in this Fluge and Mella study, then it is possible that different pathogens may cause these blockages by different mechanisms. So you would get the same sort of ME/CFS symptoms, but the mechanism of blockage may be different across the various pathogens associated with ME/CFS.
Furthermore, a wide variety of infectious triggers points to the actual trigger of me/cfs being the response to the infection, rather than the infection proper.
Not that wide really, in practice:
Let's assume that 55% of ME/CFS cases can be attributed to enterovirus. Then in
this post, I calculated that 20% of ME/CFS cases can be attributed to EBV.
So as a very rough assessment, 75% of all ME/CFS cases might be attributable to enterovirus or EBV.
Then all the other pathogens linked to ME/CFS will only account for 25% of ME/CFS cases.