Mestinon side effects?

[Thegriz]

Just started taking Mestinon or pyridostigmine, having stomach discomfort, did your body adjust to this after taking it for awhile?

 

[Mel9]

Just started taking Mestinon or pyridostigmine, having stomach discomfort, did your body adjust to this after taking it for awhile?

Yes, that’s very common. My body adjusted to 30 mg a day. I then gradually increased over six months.
What dose are you on?
Can you halve it until you get over the worst of it?

 

[Thegriz]

Started 30mg per day, just looking for some hope that this wont happen everytime i take this in the future

 

[Bander]

I had stomach and intestinal discomfort when I started on Mestinon, but it got better. I gradually increased the dose over a three week period to give some time for my body to adjust.

 

[Mel9]

I had stomach and intestinal discomfort when I started on Mestinon, but it got better. I gradually increased the dose over a three week period to give some time for my body to adjust.

Started 30mg per day, just looking for some hope that this wont happen everytime i take this in the future

Me too. It did get better.
But another way would be to halve the dose for a while, then gradually increase the dose.

 

[Learner1]

I had been doing well on compounded pyridostigmine, as I'm allergic to the fillers in all the FDA approved versions, but it has become unavailable, so I am looking into Huperzine A as an alternative. I'm hoping the Huperzine has fewer digestive system effects. I had occasional nausea and regular cramping and bloating on 30mg taken 3 times a day, which seem to be known side effects.

 

[voner]

@Learner1,

If you trial Huperzine A, I would like to hear of your comparision of it to Mestinon. I quit Mestinon due to the side effects you mentioned.

 

[Learner1]

I will post here. I am running out of pyridostigmine, so it'll be in the next couple of weeks. I may try neostigmine also, but I fear it may be worse...

 

[Mel9]

I will post here. I am running out of pyridostigmine, so it'll be in the next couple of weeks. I may try neostigmine also, but I fear it may be worse...

Do you know if it is important to taper off Mestinon?

Is it safe to stop abruptly? (I tried to Google this but couldn’t find anything quickly)