1. M

    Addressing blood pooling

    Vascular dysregulation has been one of my most pressing Long covid symtoms. The worst part about it is the blood pooling in my feet. In the beginning I could sit up to work without issues. Around one year into the illness, I had one episode where I believe I overexerted myself, mainly my legs...
  2. M

    Any Dr. Systrom patients here? - Mestinon (Pyridostigmine bromide) and safety profile

    Hello, So I got a prescription for Mestinon from my doctor to see if it helps with exertional intolerance (most notably pain/discomfort after exercise). I am freaking out about it though. For those that are not aware, this drug has been linked as a causal factor in Gulf War Illness (GWI). This...
  3. Peajay69

    Mestinon and Magnesium?

    I have very severe ME. Does anybody know if it's OK to continue supplementing Magnesium while on Mestinon? I'm currently taking 20mg X 4 a day and getting quite severe muscle twitching. I previously injected Magnesium Sulphate weekly but have recently stopped due to hearing conflicting opinions...
  4. Pearshaped

    for those who got worse with mestinon

    Dr.Systrom seems to have quite a success with Mestinon on his patients. I'd be interested to hear what others WHO GOT WORSE on Mestinon found to be helpful. Im also wondering if you are mild/moderate or severe and how onset of ilness was.My naive hope is to find similarities in our group and...
  5. tiredgirl928

    mestinon vs LDN

    Hi all! I have just received prescriptions for mestinon and LDN (yay!!). Has anyone taken both of these medications? Should I start them at the same time or try one for a few months and then add the other? If I do that, which should I start with first? I would also appreciate any information...
  6. Thegriz

    Mestinon side effects?

    Just started taking Mestinon or pyridostigmine, having stomach discomfort, did your body adjust to this after taking it for awhile?
  7. mattie

    Poll: Mestinon Trial

    A bit late, but I promised to report about Mestinon Trial (@echobravo) My new GP takes M.E. seriously. :thumbsup: Not only that, he allows me to trial Mestinon without going through a specialist which would be the normal route for this kind of off-label medication use. It works well for a...
  8. charlie1


    I've been prescribed 180 mg Mestinon SR once/day. I will begin it when I am feeling better (flu-like symptoms presently). Does anyone have any experience with this drug?