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@joshua.leisk
I think you will like this :
https://www.medrxiv.org/content/10.1101/2020.04.20.20068056v2
I have heard theories previously that androgens are why men experience colds/flus more intensely than women aka man flu.
@joshua.leisk
I think you will like this :
https://www.medrxiv.org/content/10.1101/2020.04.20.20068056v2
Your absolute courage and determination are absolutely a beacon to us all.Lost all my energy. No immune response. But Joshua is just great and does everything to find things out. Will continue.
For me, reading through all this I do agree with the underlying thesis, however the approach of using so many supplements is going to lead to all kinds of interactions with people's secondary conditions. Why not take a more personalised approach if one is willing to do the research to understand effects?
- For example; NAC according to supp.ai has 615 possible interactions between Acetylcysteine and the following drugs and supplements. If you react strongly enough to that alone you're unlikely to be able to continue with the protocol. I'm bringing up NAC specifically because thanks to this thread I decided to retry it as I'm in a state of improved health now but at two 50mg dosages throughout the day. Seemed to have a beneficial effect, I was flying around fighting aliens in my dreams in a good way. I'll continue to titrate up the dosage and unblock things but I can't imagine it would be wise for me to do all of this at once
- If you are tracking your microbiome, you may be able to do better than the InnovixLabs Multi-Strain Probiotic 50 Billion probiotic although it does look to be a diverse one it may aggravate overgrowths if there is a lot of dysbiosis? Unsure on that one.
- Why are we using the same dosages across people with a range of severity and weight etc?
- Is the glycine/NAC + liposomal glutathione redundancy to ensure glutathione needs are sufficiently met.
Thank you very much, we really appreciate that!Your absolute courage and determination are absolutely a beacon to us all.
Know that I'm not just aimlessly cheering for you, I'm deeply pulling for this protocol to produce a lasting improvement for you that can be further built on, hopefully, but that at least will pull you out of the disappointment of the post-Abilify downturn. Your fearlessness deserves nothing less ....
PS .... Hi to @Push Fwd ....
I am not sure but I think @BrightCandle might be female. However I agree with you @Marylib would be nice to know the balance as it does mainly seem to be men who've responded and gone into remission.
I know bright candle said her headaches have gone completely after years of not being able to get it sorted.
I think the key aspect there was that you weren’t taking any beta-glucans. They control the immune response in the serum.I did not. I got fluish for the first couple of days on low carb, but I think that was the keto flu....as my blood draw that day actually showed a decrease vs increase in white blood cells.
Yes. “A new hope” is the latest one.@joshua.leisk are these the latest papers? I'm moderate/severe and prepare myself slowly to go for it. Did any severe patient follow your protocol? Thanks man!
One thing I’ll remind people is that the diet is a critical component of this model / method.yes briefly but it only lasted around 2 days.. Its never been as debilitating or painful as Joshua said we should expect. It seems to come and go but often its quite mild, the last one was a few days ago. I've been experimenting with different variables to try and figure out whats going on, it seems to often coincide with with a rise in EGCG ( green tea extract ), but if I maintain it at the higher level the fever doesn't persist. Tried raising vitamin D this week and I have a feeling it made me worse, but it could just be a normal crash caused by over exercise.
My general experience on the protocol is an overall reduction of negative symptoms e.g. aches and pains, headaches, brain fogs, needing to sleep multiple times per day, MCAS, stomach issues etc. I get up the stairs much easier and more recently I've noticed that in some more ... private areas of life my stamina increased in seemingly impossible ways. Downside is I haven't been able to study science properly since starting the protocol, my brain seems like it wants to stay switched off in some ways, but in other tasks and general feeling its similar or better. Also it seems that if I do crash and the negative symptoms come back, I can lessen it with 5g BCAA, Joshua says 10g but that would be an overdose according to the label. Succinnic acid also removes all the aches and feeling of lactic acid / low oxygen etc, but it doesn't seem to fully restore energy / fitness when you are in that super tired worn out state, whereas the first time I took it, it seemed to unlock my full potential.
I think one conceptual aspect around this is that the protocol is designed to cause an intense immune response and attack every problematic tissue in your body.That's one of my issues with the protocol. I feel like there needs to be a stepwise approach, especially for those who are severe or have comorbid MCAS or issues with supplements. I can't see how it's possible to go from 0 to 12g glycine, 16 multi caps, 4 high dose R-ALA, 2400mg NAC, 10g creatine, 14 BCAA caps, sodium benzoate, etc. Just the digestive stress alone would keep me from that.
I'd love to see a way to ease into the program. I'm trying to start off with LOLA (instead of sodium benzoate), small amounts of BCAA and glycine, NAC 1-2 times per day, and a couple other items. But I'm unsure of the importance of each supplement, so I wish I had either a priority list or an explanation of the goals. I don't need to push through 'the 4 days' so quickly, unless that's an important part of the intervention?
And are different probiotics okay? Would eating yogurt suffice? Is ascorbic acid important? Is the type of multi important - or is a multi important at all? Is 20k IU of vitamin D for four days (in addition to presumably 2k IU or so in a multi) important? Are BCAAs important? Should BCAA, glycine, NAC, LOLA be taken at the same time, or will they compete? Should amino acids be taken on an empty stomach or full stomach?
I'm going to hopefully discuss more with Josh and then I can detail my own experiences.
Can you describe this more? What sequence / symptoms are you noticing?@joshua.leisk i’ve been thinking about this a lot, and as far as I can see, physically pushing myself causes an immune response which my body then freaks out about and starts to shut down. So why would we need to take something to cause the immune response, couldn’t we just do something that would normally aggravate it?
Thanks
One thing about the protocol design is that it’s aimed to cover a wide range of circumstances, rather than individual circumstances. It works on the assumption of “worst case scenario”, in that respect.Agree, we should remind us of the safe strategy to better start with lowest possible doses and increase them gradually over time. The few weeks or months maybe lost might not be as much as very severe reactions to some of the very high doses.
Right away 20 g of Glycine and 10 g of Creatine Monohydrate per day might cause gastrointestinal disstress in some. Up to 900 mg of R-ALA might cause a more consequental redistribution of mercury in at least a few. And with up to 3g NAC pulmonary hypertension might become a possibility for others susceptible already.
Lets not forget at this stage this is a completely experimental protocol. I would only increase very gradually to the full doses, and replace some of the incertain ingretients with safer alternatives. Like for example some Cystein for NAC.
Exactly. Why would I even need a probiotic since my ubiome showed more diversity than 93% of all tested?
Or high doses, while actually weighting 60kgs only?
Or such extensive glutathione supports, since my lab-test showed its already up?
Can you describe this more? What sequence / symptoms are you noticing?
Cheers
My observations and experiences suggest this is the usual ammonia and cascade. Many of the things you mention are described in the model as downstream of Acetyl-CoA depletion and therefore related to impaired beta-oxidation pathway.when I crash I will usually get very sleepy and have to go to bed and usually lie there for several hours in a semi-conscious state, sometimes in a silent migraine state too with neuro issues, then when I wake up the next day I will experience flu-like symptoms - the feeling of a head cold coming on, aching muscles, sometimes POTs symptoms and an overall weakened resilience to activity so everything is much harder to do than my usual baseline, it's the malaise feeling you get at the start of flu, plus autonomic symptoms and other weird stuff. Is that not the immune response? I always thought it was my immune system kicking in, isn't that what PEM is?
Well, one method for testing that would be to try the ammonia, Acetyl-CoA remediation methods and see if it lifts over the next 2 hours.ok thanks, makes sense. How would I know if it was an immune response then? ie how would it be different?
NAC lifts the toxic/flu brain feeling but doesn’t help the muscles in my back which are my main trigger for a crash.Well, one method for testing that would be to try the ammonia, Acetyl-CoA remediation methods and see if it lifts over the next 2 hours.