Martin aka Paused and H.E.L.P treatment

SWAlexander

SWAlexander

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Prevalence of readily detected amyloid blood clots in ‘unclotted’ Type 2 Diabetes Mellitus and COVID-19 plasma: a preliminary report
from Resia Pretorius

Abstract
Background
Type 2 Diabetes Mellitus (T2DM) is a well-known comorbidity to COVID-19 and coagulopathies are a common accompaniment to both T2DM and COVID-19. In addition, patients with COVID-19 are known to develop micro-clots within the lungs. The rapid detection of COVID-19 uses genotypic testing for the presence of SARS-Cov-2 virus in nasopharyngeal swabs, but it can have a poor sensitivity. A rapid, host-based physiological test that indicated clotting severity and the extent of clotting pathologies in the individual who was infected or not would be highly desirable.
Methods
Platelet poor plasma (PPP) was collected and frozen. On the day of analysis, PPP samples were thawed and analysed. We show here that microclots can be detected in the native plasma of twenty COVID-19, as well as ten T2DM patients, without the addition of any clotting agent, and in particular that such clots are amyloid in nature as judged by a standard fluorogenic stain. Results were compared to ten healthy age-matched individuals.
Results
In COVID-19 plasma these microclots are significantly increased when compared to the levels in T2DM.
Conclusions
This fluorogenic test may provide a rapid and convenient test with 100% sensitivity (P < 0.0001) and is consistent with the recognition that the early detection and prevention of such clotting can have an important role in therapy.
https://link.springer.com/article/10.1186/s12933-020-01165-7
 
L

lenora

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Hi @Martin aka paused||M.E......I think @Marylib was thanking you for what you do share....as do I. Yes, I understand that all can't be disclosed because it is a study and you don't want to lose the favor of the researchers who reach out to you. But when the time comes......!

How has you been depression been. I gather somewhat better b/c you haven't mentioned it and you did change your picture back again.
Sadly, a lot of our members aren't doing too terribly well at the moment. Here's a huge feel better for everyone and thanks for being such a big part of this Forum. That includes you, Martin. Yours, Lenora.
 
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Martin aka paused||M.E.

Martin aka paused||M.E.

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lenora said:
Hi @Martin aka paused||M.E......I think @Marylib was thanking you for what you do share....as do I. Yes, I understand that all can't be disclosed because it is a study and you don't want to lose the favor of the researchers who reach out to you. But when the time comes......!

How has you been depression been. I gather somewhat better b/c you haven't mentioned it and you did change your picture back again.
Sadly, a lot of our members aren't doing too terribly well at the moment. Here's a huge feel better for everyone and thanks for being such a big part of this Forum. That includes you, Martin. Yours, Lenora.
Click to expand...
Thank you very much. But your impression is wrong: its not about that I don't want to forget it with the researchers who share there data with me but it's about that I don't want to get in the way of a possible very important publication.
 
Martin aka paused||M.E.

Martin aka paused||M.E.

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Folks,

I have done some blood work and a blood smear with the help of my doc. Now I can share the results because it does not affect the NDA:

I don’t have blood clots. But my blood smear shows lipids everywhere in the blood. I haven’t talked to Dr Jaeger or Prof Pretorius yet but my doc has no idea what could be the reason and if it is part of the disease.

Lipids can cause low blood flow in the small blood vessels too. H.E.L.P. apheresis was actually invented to remove lipids (not fibrinogen). But the following blood results are very puzzling (and normally I have low pyruvate and lactate acidosis… here it shows normal results though I’m not better in any way… maybe it’s not reliable to measure it in periphery NaF blood?).
0A35AB6D-8F33-473C-9FA8-C9CE88BBD54B.jpeg
 
SWAlexander

SWAlexander

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Martin aka paused||M.E. said:
Folks,

I don’t have blood clots. But my blood smear shows lipids everywhere in the blood.
Lipids can cause low blood flow in the small blood vessels too.
View attachment 45979
Click to expand...
Hi Martin,
I think I asked this before: since your blood shows Lipids (can cause low blood flow in the small blood vessels) Did you ever have a blood test for VLCFA (Fatty acids are generally long chains of hydrocarbons with a carboxylic acid)? (VLCFA simple test in Germany. I have if you need the order-slip and Lab address.)
And if you had an Albumin urin test?
 
Martin aka paused||M.E.

Martin aka paused||M.E.

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SWAlexander said:
Hi Martin,
I think I asked this before: since your blood shows Lipids (can cause low blood flow in the small blood vessels) Did you ever have a blood test for VLCFA (Fatty acids are generally long chains of hydrocarbons with a carboxylic acid)? (VLCFA simple test in Germany. I have if you need the order-slip and Lab address.)
And if you had an Albumin urin test?
Click to expand...
I haven’t done these tests no. I only have had measured Album in my blood
 
BrightCandle

BrightCandle

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Martin aka paused||M.E. said:
Folks,
I don’t have blood clots. But my blood smear shows lipids everywhere in the blood. I haven’t talked to Dr Jaeger or Prof Pretorius yet but my doc has no idea what could be the reason and if it is part of the disease.
Click to expand...

I find the lipid reduction supplement list a little interesting given that because I know I feel better on berberine, niacin and EGCG especially (which is green tea extract). There has been a bunch of talk of the use of statins for long covid and ME too which has confused people, well they inhibit cholesterol synthesis so that explains why they were used, to reduce the lipids. Is this why Niacin works for a bunch of long haulers too?

After the paper on immunometabalism yesterday I am fairly certain I am a type M2 BPAA backup metabolism user and that definitely helps me choose how to fuel myself going forward to maximise what I can get out of that process.

Thank you for this its helpful I think and it gives people something to test in blood tests to see if they are also similarly afflicted.
 
BrightCandle

BrightCandle

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Martin aka paused||M.E. said:
Interesting because I was not improving on Josh’s protocol and crashed on berberine.

I must have missed that paper but it sounds a big like Stingl's paper?!
Click to expand...

Just a theory but if you are a M1 backup metabolism user then you are using fat energy burning with smaller amounts of BCAA and low carbohydrates. If that were the case reducing lipids would make you worse, it would take away your energy. One of the reason ME patients all have high triglycides and cholesterol is precisely because our body is using more of this for energy, its a consequence of the faulty metabolism. It also means its not a root cause in itself although very high lipids could themselves further the oxidation issue.

The paper- https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8409979/
 
Shanti1

Shanti1

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Martin aka paused||M.E. said:
I don’t have blood clots. But my blood smear shows lipids everywhere in the blood. I haven’t talked to Dr Jaeger or Prof Pretorius yet but my doc has no idea what could be the reason and if it is part of the disease.
Click to expand...
Wow, thanks for sharing these findings with us. May I ask if your standard lipid profile shows elevated cholesterol or triglycerides? I remember that you had very elevated LpPlac2, which surely ties in. Thanks!
 
SWAlexander

SWAlexander

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H.E.L.P. Apheresis
perrier said:
Thank for posting this. I am bewildered why no one on the North American continent (as far as we know) is not checking this out. Have any North American CFS/ME doctors commented? I have not heard.
Click to expand...

So far I have not seen any postings on Twitter, besides Dr. Khan.
I´have talked to German Hematologists and they seam to be stunned, but don´t like to train in fluorescence microscopy technique or invest in H.E.L.P. Apheresis. People with vWF and inflammation are doomed.
 
Martin aka paused||M.E.

Martin aka paused||M.E.

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2,291
BrightCandle said:
Just a theory but if you are a M1 backup metabolism user then you are using fat energy burning with smaller amounts of BCAA and low carbohydrates. If that were the case reducing lipids would make you worse, it would take away your energy. One of the reason ME patients all have high triglycides and cholesterol is precisely because our body is using more of this for energy, its a consequence of the faulty metabolism. It also means its not a root cause in itself although very high lipids could themselves further the oxidation issue.

The paper- https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8409979/
Click to expand...
Thank you I’ve read it. Sounds indeed like M1 but I’m puzzled because the severe cases seem to be within the M2 group.
And you’re right: apheresis and cholesterol reducing agent might make things worse. The downside is the increased risk for heart attack and stroke.
 
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