Martin aka Paused and H.E.L.P treatment

[godlovesatrier]

Well I've been on nattokinase for awhile but Stephen Buhner is very clear that Lumbronkinase is the most potent one and really I do not understand why they've got natto first.

I do think the natto is probably helping me. Joshua Leisk is adamant about taking aspirin, nac and sodium bicarb to both prevent acute disease from covid and treat LC. So I find it amazing that they are telling people to basically take the same things. He's able to correct people's abnormal red blood cells in 4 weeks taking these 3 things.

I'll be adding lumbronkinase when it arrives tomorrow. I'd say I've noticed a marginal improvement. But I won't see the full benefits (if there even are any) for several months. It takes ages for the body to calm down and get back to a good place after the vaccines. But the nac bicarb and aspirin certainly get you well inside 4 weeks for most. He's proven this with healthy and sick individuals who had mild or severe vaccine injury.

At any rate I've noticed mild improvements in my ME so this is worth noting (but I take a lot of things working on different disease symptoms). Give it a go by all means hopefully it will make a big difference.

 

[Martin aka paused||M.E.]

Well I've been on nattokinase for awhile but Stephen Buhner is very clear that Lumbronkinase is the most potent one and really I do not understand why they've got natto first.

I do think the natto is probably helping me. Joshua Leisk is adamant about taking aspirin, nac and sodium bicarb to both prevent acute disease from covid and treat LC. So I find it amazing that they are telling people to basically take the same things. He's able to correct people's abnormal red blood cells in 4 weeks taking these 3 things.

I'll be adding lumbronkinase when it arrives tomorrow. I'd say I've noticed a marginal improvement. But I won't see the full benefits (if there even are any) for several months. It takes ages for the body to calm down and get back to a good place after the vaccines. But the nac bicarb and aspirin certainly get you well inside 4 weeks for most. He's proven this with healthy and sick individuals who had mild or severe vaccine injury.

At any rate I've noticed mild improvements in my ME so this is worth noting (but I take a lot of things working on different disease symptoms). Give it a go by all means hopefully it will make a big difference.

Sorry folks,
I would like to bump it up and get back to topic. I’m completely clueless why I have so much lipids and what to do.

The new study by Mella and Fluge shows that it might be the fuel for the cells bec glycolysis is broken. And indeed I often have low pyruvate which points to a maybe enzymatic problem. I think of a allosteric or competitive inhibition. I also have slightly elevated glucose levels (without any signs for Diabetes) so that might point to unused carbohydrates.

My point is: if glycolysis is somewhat dysfunctional and the cells now use lipids as fuel it might be bad to remove them.

What are your thoughts ? @Shanti1 @Hip and others ?

Thank you!

 

[lenora]

Hi @Martin......I also have high cholesterol, at my age it's very high. Even before that though, I had high cholesterol since they began testing it.

Eventually I developed Diabetes II, which I controlled eventually myself. It's borderline at the moment. Just follow your tests and stay away from foods that may make contribute to the glycolysis. I move in and out of this state and yes, you can be a low weight and still develop diabetes II. Good luck. Yours, Lenora.

 

[Irat]

My guesses (cause I have the same problem)

A) Is a sluggish liver .because the liver has to break down cholesterol
B) with high oxidative stress the body produces more cholesterol for cell repair

C) high blood sugar,same.if the liver is weaken due to pathogenic activity and other poison,it can t store glucose and glycogen as it used to,hypo or hyperclycemia can happen.

plus oxidative stress can cause high blood sugar,because when the body is under stress, the adrenal glands trigger the release of glucose stored in various organs, which often leads to elevated levels of glucose .....

@Martin aka paused||M.E.

 

[Hip]

I’m completely clueless why I have so much lipids and what to do.

The new study by Mella and Fluge shows that it might be the fuel for the cells bec glycolysis is broken. And indeed I often have low pyruvate which points to a maybe enzymatic problem. I think of a allosteric or competitive inhibition. I also have slightly elevated glucose levels (without any signs for Diabetes) so that might point to unused carbohydrates.

My point is: if glycolysis is somewhat dysfunctional and the cells now use lipids as fuel it might be bad to remove them.

I have not seen the new Fluge and Mella paper, but if you are speculating that burning fat is an important source of you, then note that L-carnitine can improve efficiency of fat burning on mitochondria.

When I was healthy, I used to take around 1500 mg of L-carnitine 2.5 hours before going to the gym (I found it takes a good 2 hours to kick in), and I would find my very poor stamina (which I always had since a child) was dramatically improved, and I could do 3 hour heavy workouts at the gym without feeling tired in the slightest. Without carnitine, I'd poop out at the gym after 30 minutes.

 

[Martin aka paused||M.E.]

I have not seen the new Fluge and Mella paper, but if you are speculating that burning fat is an important source of you, then note that L-carnitine can improve efficiency of fat burning on mitochondria.

When I was healthy, I used to take around 1500 mg of L-carnitine 2.5 hours before going to the gym (I found it takes a good 2 hours to kick in), and I would find my very poor stamina (which I always had since a child) was dramatically improved, and I could do 3 hour heavy workouts at the gym without feeling tired in the slightest. Without carnitine, I'd poop out at the gym after 30 minutes.

I have tried that without any success. But thanks for your advice!

 

[Martin aka paused||M.E.]

My guesses (cause I have the same problem)

A) Is a sluggish liver .because the liver has to break down cholesterol
B) with high oxidative stress the body produces more cholesterol for cell repair

C) high blood sugar,same.if the liver is weaken due to pathogenic activity and other poison,it can t store glucose and glycogen as it used to,hypo or hyperclycemia can happen.

plus oxidative stress can cause high blood sugar,because when the body is under stress, the adrenal glands trigger the release of glucose stored in various organs, which often leads to elevated levels of glucose .....

@Martin aka paused||M.E.

That’s congruent with what I have learned but unfortunately doesn’t solve my problem.

 

[Hip]

I have tried that without any success. But thanks for your advice!

It does not work for me either, even though it worked well when I was healthy. I have not seen many ME/CFS patients report benefits from L-carnitine.

I find acetyl-L-carnitine 1000 mg daily however helps reduce my brain inflation a bit (the inflammatory feeling in the head).

 

[Irat]

That’s congruent with what I have learned but unfortunately doesn’t solve my problem.

I believe a slow liver cleanse over a long period of time can help for a start

 

[Martin aka paused||M.E.]

I believe a slow liver cleanse over a long period of time can help for a start

You mean avoid drugs etc?

 

[Akasha]

Sorry folks,
I would like to bump it up and get back to topic. I’m completely clueless why I have so much lipids and what to do.

Are they free in you blood? I looked at blood smears in which you can see lipids by microscopy. They are big, but I assume not enough by themselves to induce endothelial damage, right? That's why I'm asking if they are attached to some other molecules.

I'll take a look to the new paper from Fluge and Mella.

 

[Irat]

You mean avoid drugs etc?

Well as we know drugs go through the liver and of course burden it........but with a liver cleanse I mean mainly diet and some supplements like milk thistle for example.and some herbs ........which diet/liver cleanse is best for you is up to you.,if you go for example the medical medium liver cleanse protocol,or Dr.Berg healthy keto liver cleanse....

A good start is fresh lemon water in the morning....

Our liver is our detox powerhouse with over 500 vital functions

 

[Martin aka paused||M.E.]

Are they free in you blood? I looked at blood smears in which you can see lipids by microscopy. They are big, but I assume not enough by themselves to induce endothelial damage, right? That's why I'm asking if they are attached to some other molecules.

I'll take a look to the new paper from Fluge and Mella.

Afaik they are free. I don’t know what effect they have on endothelial cells. But my Lp-PLA2 shows endothelial inflammation. If it’s caused by the lipids - I don’t know!

 

[Shanti1]

I’m completely clueless why I have so much lipids and what to do.

The new study by Mella and Fluge shows that it might be the fuel for the cells bec glycolysis is broken. And indeed I often have low pyruvate which points to a maybe enzymatic problem. I think of a allosteric or competitive inhibition. I also have slightly elevated glucose levels (without any signs for Diabetes) so that might point to unused carbohydrates.

My point is: if glycolysis is somewhat dysfunctional and the cells now use lipids as fuel it might be bad to remove them.

Hi @Martin aka paused||M.E.
You had mentioned before that you have high cholesterol, I am wondering how high and if the triglycerides were also very high. Lipid droplets on a blood smear have been documented in people with extremely elevated lipids. Were you fasting when the blood smear was taken?

Blood Smear in a Patient With Very Severe Hypertriglyceridemia
The existence of multiple small fat droplets on the erythrocytes at peripheral blood smear is a particularly important observation in patients with very severe hypertriglyceridemia. These findings emphasize the importance of a simple tool such as a peripheral blood smear for early detection of very severe hypertriglyceridemia. Like the lipemia retinalis, the fat droplets will completely resolve after reduction of triglyceride levels.

People who have moderately high cholesterol wouldn't typically exhibit lipid droplets on a blood smear as fats are carried as part of a lipoprotein, which allows them to be water-soluble. Lipoproteins are very small and visible only with an electron scanning microscope. It is only when the fats in the blood are excessively high that you would expect to see them as free-floating accumulations. It is not any stretch for me to think that lipid droplets in the blood and such a high LpPLA2 are contributors to endothelial dysfunction and poor oxygen delivery. If you do have very high cholesterol/triglycerides, has it always been that way or just since ME/CFS diagnosis? Does it run in the family?

As far as lowering lipids having a consequence on your ability to utilize fats for energy, my though is that lowering them is not a problem. The body/cells are designed to uptake fats in the form of lipoproteins, not accumulated lipid droplets and should be able to do so with normal lipoprotien levels in the blood.

Of course we don't have visability to the specifics of your metabolism, but lets say you do have a problem with glycolysis or maybe you convert all your pyruvate to lactic acid because of an inhibition of the pyruvate dehydrogenase enzyme, or because your tissues aren't getting enough oxygen to utilize oxydative phosphorylation. Fatty acids and ketones can bypass the pyruvate dehydrogenase enzyme and enter the Krebs Cycle as Acetyl CoA, going on to produce the higher ATP count.... but only if oxygen is available.

My guess is that your cells will not suffer from a lack of fuel if you lower your lipids, but that the inability to produce energy is due to lack of oxygen delivery to tissues, or something else directly inhibiting mitochondrial function such as a pathogen, toxin or the mitochondria going into a "cell danger" response" from a precieved threat, rather than the inability of your cells to efficiently sequester lipoprotiens from your blood.

High lipids can also contribute to insulin resistance which would lead to high blood sugar, which then, unfortunately, contributes to higher triglycerides. It might be worth checking your fasting insulin at some point.

I hope all of that helps

 

[SlamDancin]

@Shanti1 Fwiw I just checked my own stats and in February of 2021 my Cholesterol was elevated but Triglycerides were normal range. I’ve had ME for at least five years if not 10 now. I seem to remember Tg being high before during earlier stages of the illness, which also were more severe.

 

[HealingFalcon]

Sorry folks,
(...)


My point is: if glycolysis is somewhat dysfunctional and the cells now use lipids as fuel it might be bad to remove them.

What are your thoughts ? @Shanti1 @Hip and others ?

Thank you!

According to my OAT I am not able to use carbonhydrates for energy.
Also, my lactate is and was always high (even as a child). Pyrovate is quite inconsistent and sometimes low, sometimes completely normal.
My Triglycerides went from around 50 before ME to around 270mg/dL with ME.
I did one HELP apheresis already which crashed me a lot and I am not back to baseline over a month later. Not sure if the apheresis or the transport and upright time crashed me but it could be the latter as I am severe and bedbound.

Interestingly, I do have two homozygotous genes for familiar hypercholesterolimia. However, my Triglycerides only became high after encountering ME. (Epigenetics?)
D-Dimer and Antiplasmin came back high as well which makes me think some clots could be at play although there was not much filtered out in the maschine and nobody looked for visible clots in my blood...
In addition I have high coagulation and a fast sedimentation rate.

I don't have anything to contribute other than my lab values and experience which might be interesting for you.

If we would use the Triglycerides for energy, why are they very high in our blood and not low?

 

[perrier]

According to my OAT I am not able to use carbonhydrates for energy.
Also, my lactate is and was always high (even as a child). Pyrovate is quite inconsistent and sometimes low, sometimes completely normal.
My Triglycerides went from around 50 before ME to around 270mg/dL with ME.
I did one HELP apheresis already which crashed me a lot and I am not back to baseline over a month later. Not sure if the apheresis or the transport and upright time crashed me but it could be the latter as I am severe and bedbound.

Interestingly, I do have two homozygotous genes for familiar hypercholesterolimia. However, my Triglycerides only became high after encountering ME. (Epigenetics?)
D-Dimer and Antiplasmin came back high as well which makes me think some clots could be at play although there was not much filtered out in the maschine and nobody looked for visible clots in my blood...
In addition I have high coagulation and a fast sedimentation rate.

I don't have anything to contribute other than my lab values and experience which might be interesting for you.

If we would use the Triglycerides for energy, why are they very high in our blood and not low?

Did you HELP with Dr Jaeger? Are you doing more? Thank you

 

[Marylib]

According to my OAT I am not able to use carbonhydrates for energy.
Also, my lactate is and was always high (even as a child). Pyrovate is quite inconsistent and sometimes low, sometimes completely normal.
My Triglycerides went from around 50 before ME to around 270mg/dL with ME.
I did one HELP apheresis already which crashed me a lot and I am not back to baseline over a month later. Not sure if the apheresis or the transport and upright time crashed me but it could be the latter as I am severe and bedbound.

Interestingly, I do have two homozygotous genes for familiar hypercholesterolimia. However, my Triglycerides only became high after encountering ME. (Epigenetics?)
D-Dimer and Antiplasmin came back high as well which makes me think some clots could be at play although there was not much filtered out in the maschine and nobody looked for visible clots in my blood...
In addition I have high coagulation and a fast sedimentation rate.

I don't have anything to contribute other than my lab values and experience which might be interesting for you.

If we would use the Triglycerides for energy, why are they very high in our blood and not low?

@HealingFalcon - Thanks for using your energy to make a comment. Sorry to hear that the HELP apheresis has you in a crash. I'm kind of surprised that no one looked for microclots in your blood prior to giving you the treatment. But like many of us, I am sure you felt it was worth a try. Maybe the benefit will go to a subset specific to SARSCoV2 infection or those previously healthy people injured by the vaccines. I know one of the latter who is watching what happens with these trials, but his impression (he is a research professional) is that the injuries kind of fall into two camps: diagnosable vascular issues, such as (thrombosis) and autonomic nervous system dysfunction. I hope you feel better soon.

 

[HealingFalcon]

Did you HELP with Dr Jaeger? Are you doing more? Thank you

No. I did it in one of the other HELP apheresis clinics in Berlin which is the reason my blood wasn't studied before...and for now there is no possibility to get it examined.

I have more appointments sheduled but had to cancle each until now. We will see...

 

[HealingFalcon]

@HealingFalcon - Thanks for using (...) I know one of the latter who is watching what happens with these trials, but his impression (he is a research professional) is that the injuries kind of fall into two camps: diagnosable vascular issues, such as (thrombosis) and autonomic nervous system dysfunction. I hope you feel better soon.

Thanks!
It is no requirement to have clots to get the treatment. For now, is is just a trial and error...interestingly, my medical insurance even pays a part as I have very high Triglycerides, LDL and the SNPs. So I though even if I don't have clots it is a preventive treatment...

And I agree. The ANS group probably has a structural subgroup to which I belong...However, it could be (although quite unlikely) that most of these subgroup have micro clots due to different underlying factors and one treatment (HELP) can treat the majority (maybe some need continued apheresis due to persisting underlying factors)