Taking very high doses of B12 (25 mg or so) made my lunulae on my thumbs grow and become nice and white. They also made small lunulae appear on my index and middle finger, but they were nothing to brag about.
When my methylation cycle was restored, My lunulae stayed like this. Now that I need to take B12, etc every day for proper methylation as so I don't feel like complete crap, the lunulae on my index and middle finger have disappeared.
I have mentioned this numerous times in the B12/methylation part of the forum.
I'm not sure how to vote, so will abstain for now. When this subject came up last month, I looked and found lunulae only on my thumbs, but now I see that I have small crescents developing on my first and middle fingers. I've been trying Rich's methylation protocol for a couple of months so, like kday, I'm thinking this might be related to B12 intake, etc. Would be interesting if everyone trying Rich's protocol would keep a lunulae diary and report back on their findings.
Looking at the results so far, I can't help wondering, what's so special about thumbs? Why are the lalunae on the thumbs the last to go? (Not that it's important; it's just that I often wonder about life's little mysteries.)
Most of these forum polls now seem to me a bit fruitless for various reasons, which is why we are developing solutions to dramatically improve the value of the data we can collect in this way. But this one, I think, is an exception...
After this first try it might be appropriate to explore some more detail perhaps, but cigana's highlighted issue seems more important: control comparisons. How might we find our own control data for this?
Perhaps something like: everybody participating in the poll could pick one random friend whose lunula status is unknown to them - somebody who is in good health (definition of that part needs some thought), check their lunulas, and report back? For my part, I'm making a mental note to check the lunulas of as many people as I can to try to get a feel for it.
Further expansion of the study could explore more detail of the length of the lunulas on all fingers because an earlier post suggested there are more detailed patterns also; those patterns could probably be confirmed quite quickly here.
I'd love to organise such a 'study' but unfortunately I have other fish to fry...so again I'll just invite a volunteer to take this up...it shouldn't be ever so much work for a small team...
It's kind of interesting to me to hear that the methylation status may be affecting the presence or absence of lunulas. I don't understand why for sure, but that has never stopped me from offering a hypothesis in the past! -) So here's one:
It's known that the nails are composed of proteins called keratins. The mechanical strength of the nails (and the hair, which is made from the same class of proteins) is due to crosslinking between the protein molecules by formation of cystine disulfide bonds between adjacent cysteine residues. When there is a methylation problem, it tends to affect the availability of cysteine, about half of which is usually made from methionine by the combination of the methylation cycle and the transsulfuration pathway. I suspect that when there is a deficiency of cysteine, the nails and hair are made of the types of keratin that don't contain as much cysteine as are usually used. The result is likely to be weaker nails and hair.
The lunulas are the visible part of the nail matrix, which is where the new nail material is being produced. O.K., here comes the hypothesis: Maybe a shortage of cysteine slows the production of new nail material and shrinks the nail matrix, so that it retreats back underneath the cuticle.
It is known that people who have kidney disease and have to be on dialysis tend to have fewer lunulas. Several studies have shown this. It is also known that the kidneys are normally one of the organ types that are able to convert methionine to cysteine, by virtue of the fact that the kidneys have a fully functioning transsulfuration pathway (as do the liver, the pancreas, the intestine, the lens of the eye, and to a much lesser extent, the brain). So I think that this fact might be consistent with the hypothesis offered above.
I would be interested to know if others who try the methylation-type treatments (Freddd's or the one I have suggested or some variation of these or the others out there now) also experience appearance of lunulas where they were absent before.
Ooooh...keratin! So this is related to keratosis then? That peaked when I was sickest and is another good measure of my health.
What interests me most about this is the ease with which it could be a practical measure of progress with treatments. If people can monitor their lunulas and learn in real-time how well their treatment is progressing, that would be a much easier, cheaper and more effective strategy than blood tests...
Thanks, cigana - the lunula stuff begins on a thread about Dr Lapp's research, starting with this post. Overstressed thinks that the disappearance of lunulas could be due to cell apoptosis, there's a later reference to possible links to stress, someone has them returning when they've got their methylation cycle working, someone thinks it's also related to disappearing fingerprints, lots of theories... It would be good to know what the figures are for lunulas in healthy people.
Hi, i havent voted as i have strong lunulas on both thumbs and a couple of small ones on others, none at all on some, although this has improved as a few months ago only the thumbs where visible. I am taking supplements but not methylation ones specifically.
Whats weird is that my youngest daughter (8) has good ones, my son who is 10 and well has a couple barely visible and none on thumbs, my husband has very pronounced ones on all fingers and is one of the healthiest people i have ever met.