My husband has been taking super-low .75 dose for two months, dialing back from an attempted 1.5. It has caused severe, severe depression. Also, his appetite is pretty bad now. Not sure if we'll continue.
Well sad news for me. While LDN pretty much eliminated by brain fog, made me euphoric, and gave me the sex drive of a teenager for about a month, it didn't last.
Since that time I've slowly drifted back to my (almost) hobbyless life... For the last week I've pretty much just spent on the couch. I detect no positive effects of LDN anymore.
I've started playing with the dosage again to see if it can make a difference. I've read on the LDN faq that tolerance can be built towards it so I'm planning to take a month or 2 off to test that
Actually though I think there is still a positive. Marijuana and kratom still seem to work better with LDN
I think I only got up to 4mg but I started to get more fatigued at that dosage. Whether or not that was due to LDN I can't say. I ended up stabilizing at 3mg. Now I'm playing with the dosage again to see if it makes any difference
I've been off LDN for 2 days now and my achy muscles are coming back. The fatigue is only slightly better, so I don't know what to do.
If I decide to go back on it I think I will see if I can get the same benefits with just .5.
This was the case for me alas. My doctor started me out at the top dose 4mg I think. I was not a fan of it at first as it interfered with my sleep plus I had depressing dreams, but as the months went on my health picked up (cant say it was all due to LDN, I thought Kefir helped more). I certainly knew I was on it though. To try to get better quality sleep and less depressing dreams, I cut the dose back to 2mg a night for 4 nights a week. As the weeks went on it seemed like it made less difference. I then ran out and ordered some more a month later and started on the full 4mg again, Nothing. No interrupted sleep (waking at 3am + 4am) and no bad dreams, and no pick up in health or energy. I then read up how if someone has candida supposedly that blocks LDN from working properly. I had been on ABx when I was first on LDN, but then stopped and was haphazard in probiotic use and feel I was suffering from excess fungal/candida growth. I put the LDN in the fridge until I tackle the candida issue better.I've heard some people basically say that after a time the LDN on a consistent dosing schedule doesn't work, you could try staggered dosing by trying it at low levels on alternating intervals based on what you think might help.
Whether that's every other day, every two days, every three days, who knows, however as I mentioned some people have said that it may be that the body becomes accustomed to it and you may need to try and balance the positive effect with that potential outcome.