pattismith
Senior Member
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I took Clarithromycin for an infected wound and I'm feeling stimulated and less sleepy.
GABA A receptor antagonism is a well known side effect of this drug, so it may explain my reaction!
GABA A receptor antagonism is a well known side effect of this drug, so it may explain my reaction!
Clarithromycin in GABA-related Hypersomnolence: A Randomized, Crossover Trial (nih.gov)
2015
Lynn Marie Trotti, MD, MSc,1,* Prabhjyot Saini, MSc,1 Donald L. Bliwise, PhD,1 Amanda A. Freeman, PhD,1 Andrew Jenkins, PhD,2 and David B. Rye, MD, PhD1
Objective
Some central hypersomnolence syndromes are associated with a positive allosteric modulator of GABA-A receptors in cerebrospinal fluid. Negative allosteric modulators of GABA-A receptors, including clarithromycin, have been reported to reduce sleepiness in these patients. We sought to systematically assess the effects of clarithromycin on objective vigilance and subjective sleepiness.
Methods
This was a five-week, randomized, placebo-controlled, double-blind, crossover trial of clarithromycin 500 mg with breakfast and lunch, in patients with hypersomnolence syndromes (excluding narcolepsy with cataplexy) and evidence for abnormal cerebrospinal fluid potentiation of GABA-A receptors. The study occurred at a university-affiliated medical center. The primary outcome measure was median reaction time on the psychomotor vigilance task (PVT) at week 2 in each condition. Secondary outcomes included the Epworth Sleepiness Scale, Stanford Sleepiness Scale, Functional Outcomes of Sleep, Pittsburgh Sleep Quality Index, the SF-36, and additional PVT measures.
Results
Twenty-three patients began treatment. Three patients dropped out, and final analyses were performed on twenty complete cases. Median reaction time was not significantly different between clarithromycin and placebo.
Subjective measures of sleepiness were significantly improved on clarithromycin versus placebo. Altered taste perception occurred, but was the only side effect more common on clarithromycin than placebo. No serious adverse events occurred.
Interpretation
Subjective sleepiness, but not psychomotor vigilance, improved during a two-week course of clarithromycin.
Although additional studies are needed, this suggests that clarithromycin may be a reasonable treatment option in patients with treatment-refractory hypersomnolence.