picante
Senior Member
- Messages
- 829
- Location
- Helena, MT USA
I'm starting this thread because I got a tad annoyed. Reading through threads on L-carnitine, I keep running across the statement that L-carnitine can keep thyroid hormones (T3, T4) from entering cells.
Most of the time there is no documentation given (thus the annoyance). The documentation that I have seen linked is to studies done on hyperthyroidism:
http://www.ncbi.nlm.nih.gov/pubmed/15591013 (a randomized clinical trial on iatrogenic hyperthryoidism!)
http://www.ncbi.nlm.nih.gov/m/pubmed/11502782/ (a clinical trial that looked at symptoms of hyperthyroid patients)
From the second link:
I'm not at all sure this applies to those of us who are hypothyroid. My understanding is that hyperthyroidism causes urinary carnitine wasting, which would lead to deficiency, ¿no?
I've just gone in circles trying to get a bearing on this:
Here on PR we have hypothyroid people doing the deadlock quartet who say they have had improvement and had to lower their thyroid dosage. This makes sense: glutathione is needed for the conversion of T4 to T3 (http://metabolichealing.com/thyroid-solutions-glutathione-t4-t3-conversion/), and methylation protocols can increase glutathione levels.
I'm not sure it works to look at L-carnitine in isolation, in other words.
So I'm tracking my own responses to ALCar now, which is the form I've been taking lately. I'm recording my temperatures and my perception of fatigue. FYI, I'm taking a compounded T3/T4 sublingual for a combination of thyroid problems: low T4-to-T3 conversion and TPO antibodies.
So far, I'm not seeing any discernible difference in my body temperatures in the 30-60 minutes after taking ALCar. However, I usually take AdoB12 within 30-60 minutes of the ALCar. Once I take the AdoB12, I am seeing a temperature increase. I've been recording them for 5 days, and getting between .2 and .6 degrees Fahrenheit increase in 20-30 minutes after taking AdoB12.
I'm not seeing any particular pattern yet with fatigue. Fatigue seems to be more affected by eating, in my case.
Those who have posted before on L-carnitine & hypothyroidism, have you found any more clues or research?: @Sea @ahmo @SOC @South @Gondwanaland @caledonia @Freddd
Most of the time there is no documentation given (thus the annoyance). The documentation that I have seen linked is to studies done on hyperthyroidism:
http://www.ncbi.nlm.nih.gov/pubmed/15591013 (a randomized clinical trial on iatrogenic hyperthryoidism!)
http://www.ncbi.nlm.nih.gov/m/pubmed/11502782/ (a clinical trial that looked at symptoms of hyperthyroid patients)
From the second link:
Old studies in animals and unblinded studies in a few hyperthyroid patients suggested that l-carnitine is a periferal antagonist of thyroid hormone action at least in some tissues. This conclusion was substantiated by our recent observation that carnitine inhibits thyroid hormone entry into the nucleus of hepatocytes, neurons, and fibroblasts.
I'm not at all sure this applies to those of us who are hypothyroid. My understanding is that hyperthyroidism causes urinary carnitine wasting, which would lead to deficiency, ¿no?
I've just gone in circles trying to get a bearing on this:
Here on PR we have hypothyroid people doing the deadlock quartet who say they have had improvement and had to lower their thyroid dosage. This makes sense: glutathione is needed for the conversion of T4 to T3 (http://metabolichealing.com/thyroid-solutions-glutathione-t4-t3-conversion/), and methylation protocols can increase glutathione levels.
I'm not sure it works to look at L-carnitine in isolation, in other words.
So I'm tracking my own responses to ALCar now, which is the form I've been taking lately. I'm recording my temperatures and my perception of fatigue. FYI, I'm taking a compounded T3/T4 sublingual for a combination of thyroid problems: low T4-to-T3 conversion and TPO antibodies.
So far, I'm not seeing any discernible difference in my body temperatures in the 30-60 minutes after taking ALCar. However, I usually take AdoB12 within 30-60 minutes of the ALCar. Once I take the AdoB12, I am seeing a temperature increase. I've been recording them for 5 days, and getting between .2 and .6 degrees Fahrenheit increase in 20-30 minutes after taking AdoB12.
I'm not seeing any particular pattern yet with fatigue. Fatigue seems to be more affected by eating, in my case.
Those who have posted before on L-carnitine & hypothyroidism, have you found any more clues or research?: @Sea @ahmo @SOC @South @Gondwanaland @caledonia @Freddd