kynurenine pathway, social anxiety disorder

[aquariusgirl]

https://www.sciencedirect.com/science/article/abs/pii/S0889159121005961

 

[aquariusgirl]

The peripheral kynurenine pathway is altered in SAD and preferentially directed towards KYNA synthesis. Additionally, kynurenine pathway activation, as evidenced by elevated KYN and KYN/TRYP ratio, is evident in SAD patients with a history of past suicide attempt. While no differences in pro-inflammatory cytokines is apparent in SAD patients, lower anti-inflammatory IL-10 levels are seen in SAD males. Further investigation of the role of the immune-kynurenine pathway in SAD and other clinical anxiety disorders is warranted.

 

[Wishful]

No surprise to me. TRP made all my ME symptoms worse, and niacin (end product of the kynurenine pathway) made me quite strongly suicidal. Research there would be helpful.

 

[anne_likes_red]

https://www.sciencedirect.com/science/article/abs/pii/S0889159121005961

I noticed this pathway referred to in a recent presentation about the benefits of a particular strain of Bifidobacterium Longum IE: the Zenflore strain, "1714-Serenitas".. Wondered if it might be worth looking into further.
Here is the video I saw. NB It's promoting Microbiome Labs formulations of B Longum 1714. Mods remove if inappropriate.
*I purchased the Zenflore product BTW, from Europe. Going through hoops currently to get it here, but hope to have it in a couple of weeks.
Kiran Krishnan, co-founder of Microbiome Labs talking about B Longum 1714,