kynurenine pathway, social anxiety disorder

aquariusgirl

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The peripheral kynurenine pathway is altered in SAD and preferentially directed towards KYNA synthesis. Additionally, kynurenine pathway activation, as evidenced by elevated KYN and KYN/TRYP ratio, is evident in SAD patients with a history of past suicide attempt. While no differences in pro-inflammatory cytokines is apparent in SAD patients, lower anti-inflammatory IL-10 levels are seen in SAD males. Further investigation of the role of the immune-kynurenine pathway in SAD and other clinical anxiety disorders is warranted.
 

Wishful

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No surprise to me. TRP made all my ME symptoms worse, and niacin (end product of the kynurenine pathway) made me quite strongly suicidal. Research there would be helpful.
 

anne_likes_red

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I noticed this pathway referred to in a recent presentation about the benefits of a particular strain of Bifidobacterium Longum IE: the Zenflore strain, "1714-Serenitas".. Wondered if it might be worth looking into further.
Here is the video I saw. NB It's promoting Microbiome Labs formulations of B Longum 1714. Mods remove if inappropriate.
*I purchased the Zenflore product BTW, from Europe. Going through hoops currently to get it here, but hope to have it in a couple of weeks.
Kiran Krishnan, co-founder of Microbiome Labs talking about B Longum 1714,
 
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