Hope I'm allowed to post this here. Your last article "Evaluating Routine Blood Tests According to Clinical Symptoms and Diagnostic Criteria in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome"
I actually found quite fascinating. I recently had whole bloods taken so I read this article and found that it seems all the biomarkers in the study line up with my own blood test results. Which for me was really interesting!! Especially as the cohort sizes are decent.
I'll try to summarise as I'm on my phone but wanted to get a post out on this:
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So the study as you can see above did a variety of tests across 149 ME patients and 264 healthy controls.
They broke patients down by illness severity severe/moderate and mild. With a table of there results side by side and it's interesting how the deviations are on the whole small apart from some biomarkers. Of course quantifying the severity of small deviations is another topic altogether.
I guess the standout differences however for me were that creatinine and potassium were slightly lower in ME patients compared to controls but CK (creatinine kinease) was much lower in ME patients Vs controls (especially severe patients - see further down).
Interestingly my CK value was 80 which is more or less in the same ballpark as all ME patients. Whereas healthy controls the average was 121. Now as a mild patient I find it very interesting that I had milder symptoms than I had had in a long time when I got these bloods taken but ultimately my CK value is still roughly ball park for an ME cohort. I wonder if the protocol I am on (Josh's protocol listed in my signature) will ever shift these biomarkers. Off topic for this post. Just an interesting point.
Info about creatinine from my results:
Creatinine is a chemical waste molecule that is generated from normal muscle metabolism. Measurement of this is an indicator of the levels of other waste products in the body. Creatinine is also an accurate marker of kidney function, and may help in diagnosing kidney disease.
CK from my results:
Creatinine kinase (CK) is an enzyme which is necessary for muscle function and is found in the heart and skeletal muscles as well as other tissues. It signifies muscle cell damage and death and is measured to diagnose and monitor muscle damage. CK levels tend to be higher in people with greater muscle mass.
I personally see this and the result set for severe moderate and mild patients in this study as a close indicator that actually we've all got the same disease. Which might reinforce the idea that viruses and other pathogens as the years go by could be the culprit behind deterioration and severity? Who knows for sure. But I find it an interesting angle of debate as there has to be a reason why to my knowledge many of us start of mild and then we deteriorate either extremely quickly or incredibly slowly (months Vs decades).
Also I got these blood results the day before my second covid jab and on that day I felt pretty terrific. So I find it interesting as well that how you feel in terms of your ME (no sore throat, no fatigue, PEM blocked, still pacing etc (I felt this good due to the heroes veridai protocol listed in my signature - when I got the covid vaccine all these symptoms reappeared over several weeks)) in my case would seem to have had no effect on the underlying issue causing my ME. I had been on the protocol about 30 days by then.
More analysis by severity:
Severely ill patients had the lowest CK value mean average of 64. Whereas mild patients had a CK value of 88. And healthy controls as I said above had an average of 121. So severely ill patients had a 50% reduction compared to controls.
There's a lot more data here really but I need to write my own results down to see how I'm doing. I like this study I feel like it gives us data to work with instead of a black hole with nothing in it.