Is Melatonin a methyl donor?

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3
I apologize if this is not the right place to ask. But I wanted to ask if anyone knows if Melatonin is a methyl donor.
My first ever supplement of any kind was taking a 2mg Melatonin pill that also had 2mg of B6 in it. The next day and for the next 8-9 days I felt amazing(no more pain and weakness or paralysis) while continuing to take the pill every night. After that though, I started to feel gradually worse and eventually started getting a very strong pounding heart beat everytime I took the pill, and so I stopped.
Now, the reason I ask if Melatonin is a methyl donor, is because I have recently started taking MethylCobalamin, and after a few days of feeling well and sleeping well, I again started getting the pounding heart beat after taking it.
So, do you guys know if Melatonin is a methyl donor? Sorry if the bold formatting is bothersome to anyone, I just find it easier to read that way.
 

HTester

Senior Member
Messages
186
This is theoretically possible. The normal reaction that synthesizes melatonin from N-acetylserotonin is a methyltransferase and is considered reversible. So it's possible that melatonin could donate its methyl group back to S-adenosyl-homocysteine to make S-adenosyl-methionine.
 
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