One of the issues with leaky gut theories leading to autoimmunity, or indeed any autoimmune theory, is that there is some evidence that we don't fit the model. We don't seem to have one autoantibody to one target, but many autoantibodies to many targets. It is likely there is something fundamentally wrong with our B cells.
I'd be interested in discussing this in one of the leaky gut threads, alex3619, rather than take this thread too off-topic - or have we already discussed it there? I mean why different autoimmune conditions might have different/different diversities (for want of a better word) of autoantibodies. I have theorised about this but am keen to know if anyone has anything more solid.