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[my emphases]Attachment to IACFS/ME Newsletter, Vol 3, Issue 1, April 2010
Q and A Session with Dr Mikovits
Q: From what I read, XMRV is infecting immune cells, If patients take nutriceuticals that have been shown to increase natural killer cell count, could some of this increase in NK cells come from dividing infected cells, thus risking a heavier load of XMRV?
A: Because XMRV research is in its infancy, little is know about tissue reservoirs....
You could potentially increase the viral load by increasing the NK cell count. However, we have done studies with compounds that increase NK cell Killing without increasing NK replication or XMRV viral loads so NK cells kill better and can therefore be efficacious in killing XMRV infected cells.<snip>
Coinfecting viruses generate negative and positive signals the suppress or upregulate HIV-1, suggesting that signals generated by these viruses may largely affect XMRV transmission and pathogenesis as they do with HIV transmission and pathogenesis.