In states of chronic stress why does the bodies receptors not become tolerant to things like norepinephrine, yet when taking medications it does?

[linusbert]

@sb4 beware the caffeine and especially the Theobromine (which is like caffeine but works for hours or days) in cacao or dark chocolate.

 

[skwag]

Thanks @linusbert

I did not know about the Theobromine. It Might explain agitated feeling I get from dark chocolate. I'm very tolerant of caffeine so it had to be something else.

 

[SWAlexander]

I don't know if it was the vagus nerve thing or just random but my symptoms have changed up on me.

The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Tract
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01452/full​

 

[Violeta]

I don't know if it was the vagus nerve thing or just random but my symptoms have changed up on me. Now my pulse is racing but not bounding. I had a chocolate bar around dinner time and my pulse was 100+bpm whilst just sitting down for hours afterwards. This is very unpleasant but much preferable to the bounding pulse I always experience.

I think this is more how normal POTS patients are except mine is still elevated (though not by as much) when lying down.

Makes me believe my heart is compensating for poor blood flow with bounding pulse and if that fails (clonidine, alpha GPC, possibly vagal nerve stimulation) it resorts to racing pulse.

Could it be possible that chocolate is good for you?

https://pmc.ncbi.nlm.nih.gov/articl...ith some,appetite, reward and mood regulation.

 

[sb4]

Could it be possible that chocolate is good for you?

https://pmc.ncbi.nlm.nih.gov/articles/PMC3575938/#:~:text=Chocolate may interact with some,appetite, reward and mood regulation.

Chocolate is definitely a weak spot in me. I eat some chocolate most days. Though I will say, particularly with dark chocolate, my heart pounding gets worse after. With smaller amounts of milk chocolate I'm okish. Perhaps its the caffeine thats stimulating?

 

[SWAlexander]

Could it be possible that chocolate is good for you?

Using the keyword 'chocolate,' I would say the elevated pulse is due to the release of dopamine. Chocolate contains compounds like theobromine and caffeine, which act as stimulants. Dopamine, in turn, plays a role in raising blood pressure and heart rate.

 

[Violeta]

Using the keyword 'chocolate,' I would say the elevated pulse is due to the release of dopamine. Chocolate contains compounds like theobromine and caffeine, which act as stimulants. Dopamine, in turn, plays a role in raising blood pressure and heart rate.

Caffeine also causes release of glutamate and histamine.

So the chocolate stopped the bounding but caused racing.

I can't believe your body can be doing this 24/7 for so long!

Someone on Twitter says that rutin helped where propanolol didn't. She says it helps because of what it does with glutamate. Let me go check and make sure I am understanding what she said.

@sb4, have you tried GABA?

 

[SWAlexander]

Have you tried GABA

Do you mean Gabapentin?

 

[Violeta]

Do you mean Gabapentin?

No, plain GABA. I should have tagged Sb4 with that question, though.

 

[sb4]

@Violeta I have tried sublingual GABA. Maybe helped me sleep and calm me down.

The wierd thing is, with things that calm my nervous system down like beta blockers, Theanine, Magnesium Threonate, etc, my body gets more relaxed however my bounding pulse just changes but doesn't leave.

It becomes weaker / less painful however my heart rate usually picks up and I overall feel weaker and more light headed. I'm still in quite a bit of cardiovascular discomfort either way. Not only that, when I take things to relax me my pulse is still bounding to some degree, you can easily see my stomach pulsating, just not as much.

I've been thinking that because my nervous / cardiovascular system has been stuck on sympathetic for like 13 years straight that maybe it's become "stiff" in some way. Hopefully if I can get my body to be in a relaxed state for more of the day, over time it will "loosen up" and whatever is causing the resistance to blood flow will go away.

 

[Violeta]

@Violeta I have tried sublingual GABA. Maybe helped me sleep and calm me down.

The wierd thing is, with things that calm my nervous system down like beta blockers, Theanine, Magnesium Threonate, etc, my body gets more relaxed however my bounding pulse just changes but doesn't leave.

It becomes weaker / less painful however my heart rate usually picks up and I overall feel weaker and more light headed. I'm still in quite a bit of cardiovascular discomfort either way. Not only that, when I take things to relax me my pulse is still bounding to some degree, you can easily see my stomach pulsating, just not as much.

I've been thinking that because my nervous / cardiovascular system has been stuck on sympathetic for like 13 years straight that maybe it's become "stiff" in some way. Hopefully if I can get my body to be in a relaxed state for more of the day, over time it will "loosen up" and whatever is causing the resistance to blood flow will go away.

The fact that you haven't given up says a lot about your strength. I am praying you find a solution. That's a long time!

I looked through a number of these homeopathic remedies, but haven't found one that seems to cover all the bases. Homeopathy often has clues that you can't find anywhere else.

Resistence to blood flow reminds me of the videos I watched about glycocalyx. When it's stripped from the endothelial cells the blood doesn't flow through right. I still have to watch part 2 where the presenter talks about ways to correct the process.

 

[sb4]

The fact that you haven't given up says a lot about your strength. I am praying you find a solution. That's a long time!

Thank you!

Resistence to blood flow reminds me of the videos I watched about glycocalyx. When it's stripped from the endothelial cells the blood doesn't flow through right. I still have to watch part 2 where the presenter talks about ways to correct the process.

I guy called Jason at MyBioHack was recently going on about the glycocalyx and POTS and I even went as far as to buy his program for £20 but I didn't end up getting much out of it. There is some interesting information in there but his solution to it is an absolute mountain of expensive supplements that he gets commission of.

I did try a few like pycnogenol, pine bark extract, Specialized Proinflammatory Mediators, etc without much effect.

 

[Violeta]

Thank you!

I guy called Jason at MyBioHack was recently going on about the glycocalyx and POTS and I even went as far as to buy his program for £20 but I didn't end up getting much out of it. There is some interesting information in there but his solution to it is an absolute mountain of expensive supplements that he gets commission of.

I did try a few like pycnogenol, pine bark extract, Specialized Proinflammatory Mediators, etc without much effect.

I was wondering what his program was like. I didn't feel like spending the $199USD. The pycnogenol and pine bark extract were for the glycocalyx problem?

 

[SWAlexander]

No, plain GABA. I should have tagged Sb4 with that question, though.

No, I can’t take GABA because I have high phytanic acid levels (VLCFA), which is a disorder involving amino acid metabolism.
GABA is technically derived from glutamate (an amino acid) and acts as a neurotransmitter.

 

[sb4]

I was wondering what his program was like. I didn't feel like spending the $199USD. The pycnogenol and pine bark extract were for the glycocalyx problem?

Yeah they were for the glycocalyx, can't remember what they were supposed to do now.

The program itself was only £20 but if you were to take all the supplements you probably would be looking towards £1000 or something silly.

 

[Violeta]

Yeah they were for the glycocalyx, can't remember what they were supposed to do now.

The program itself was only £20 but if you were to take all the supplements you probably would be looking towards £1000 or something silly.

I don't know about you, but having to take so many supplements is overwhelming for me and basically undoable, if that's a word.

 

[sb4]

I don't know about you, but having to take so many supplements is overwhelming for me and basically undoable, if that's a word.

Yeah, even if you forget about the costs, it would be difficult physically and it just feels like you're getting conned.

Needless to say I didn't buy any supplements from the affiliate links and only tried a few of them. Perhaps if you did take them all it would have a noticeable effect on the vasculature but I'll never know.

 

[SWAlexander]

Without a thorough understanding of an individual’s comorbidities and medical history, experimenting with supplements can be harmful and may lead to setbacks rather than progress.
For example, in my case, a test was conducted after 8 weeks of avoiding meat, animal by-products from ruminant animals (such as cattle), and dark green vegetables. Despite these dietary restrictions, phytanic acid levels remained elevated.
Mention in link with image: https://forums.phoenixrising.me/thr...olic-derangement-diseases.89093/#post-2420542
In addition, dark green vegetables (rich in Vitamin K) will exacerbate bleeding risks in individuals like me with von Willebrand disease (VWD).

 

[linusbert]

In addition, dark green vegetables (rich in Vitamin K) will exacerbate bleeding risks in individuals like me with von Willebrand disease (VWD).

so vitamin K which is to reduce bleeding leads to increased bleeding? now thats nasty! but kinda fits into my experience with things which should do a thing and do the opposite.
i bought lutein/zeaxanthin medication for my eyes, it looks like my eyes need exactly that... but everytime i take it my eyes get worse... i do not understand.

 

[SWAlexander]

i do not understand

It was a very long road for me to understand.
If you like, read this:

Understanding High Phytanic Acid: Causes, Symptoms, and Management​

https://swaresearch.blogspot.com/2024/11/understanding-high-phytanic-acid-causes.html​