Yes, my MCS has improved 90% by doing Rich Vank's methylation protocol.
The reason it works is it builds glutathione in the liver. You body depletes one glutathione molecule for every toxin molecule you breathe, eat, etc. If you're low in glutathione your body can't deal with the toxins. If you increase glutathione, you can start to deal with toxins again.
In general, when you start anything new, start one thing at time so you can tell what's doing what. Start LOW and go SLOW. That means start with a fraction of a normal dose, and increase gradually as you tolerate the dose. The same thing holds true for the methylation protocol supplements.