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We have several breakthrough results in hand now which needs to be thoroughly studied.
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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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We have several breakthrough results in hand now which needs to be thoroughly studied.
I will give it a shot.Does anyone know of any attempts to take this line of research to explain any of the autonomic dysfunction that plague so many with ME/CFS?
Based on the model I put together + my own anecdotal evidence - it looks like a diet of 40%-50% calories from fat is an optimal target. Severe ME/CFS cases may benefit from (temporary) clinical/traditional ketogenic diets (75%-80% fat), however I've seen the most improvement at the 40%-50% caloric fats range personally. That combined with antioxidant support + pulsed antivirals has put me on a solid road to recovery in 2020.
Autoimmunity is common in ME/CFS (50). Several autoantibodies are capable of inducing a proinflammatory state in target cells (51). Interestingly, HHV-6 is linked to several autoimmune diseases, including multiple sclerosis and Hashimoto thyroiditis (52). Autoantibodies against β2 adrenergic receptors (β2R) were found to be upregulated in a subset of patients with ME/CFS (53). Such Abs belong to a network of natural Abs against adrenergic, acetylcholine (cholinergic), and other GPCR receptors that were shown to be dysfunctional in various autoimmune diseases (54)
That's correct. Bacterial infections have been known to do so, too.Hmm so this means the viruses turn on the autoimmunity, not the autoimmunity causes issues in the body which allow the viruses to replicate?
do you see any way that selenium would help correct any of the issues identified in Dr Prusty's paper?
Selenium is also needed for glutathione production. Glutathione is an important antioxidant that can be depleted along with vitamin C and other antioxidants in the oxidative and nitrosative stress that goes along with these viruses.The only thing I know about selenium is that people with Hashimoto’s are told to take 200mg of Selenium as well. I dunno if it‘s supporting the thyroid function or battles depletion by the disease.
@Hip, do you see any way that selenium would help correct any of the issues identified in Dr Prusty's paper?