I started with dr mercola probiotics and solaray24 strain 1 cap per day, and noticed a big difference initially with the solaray24 strain - this was 2 years ago.
I carried on with that because it got rid of my dysbiosis and abdominal pain after eating. Then I started experimenting with inulin I noticed tiny doses didn't do anything for me, but 5 g's and up had a much bigger effect. Then I noticed my physical weakness completely disappeared with prebiotics, even if I didn't take any probiotics - I'd never really felt that good on just the solaray or dr mercola.
Then I started using vivomixx but that stuff is so powerful I began to have issues when I took it every day (brainfog primarily).
However whilst doing this I was also increaseing my dose of life extension reishi for nk cell function and taking valtrex from december 2022 onwards. I got to 90% mentally on that before crashing from symbioflor2 about 4 weeks ago. Currenly recovering from the symbioflor2 crash.
I've also tried optibac lacis bb-12 with FOS - that's a good combination and I've taken FOS as a prebiotic. All of these orally.
The enema = optibac bb-12 + 5g FOS, 5g inulin and tributyrin.
But I had a lot of inflamation after the enema in my lower back - assume colon - and I felt really unwell (like I had a virus after). I'd be ok doing this for a few months to check if it's theraputic immune modulation causing the viral type pain/symptoms but I work full time so I can't.