Its been 2 months since been on sublingual methylb12, adb12 and methylfolate. I cant say i have noticed anything positive at all. Not knocking it but dont think its for me.
In the past have noticed some energy improvement with hydroxy b12injections
Well now, a few questions. How long did you let the b12 tablets stay under your upper lip pr tongue, at least 45 minutes? Did you use the brands specified?. Have you been taking the other critical cofactors, the ones without which the b12s might not do much?
For various people these include minimum 3000 IU of D3, magnesium, 50mg zinc, SAM-e (200-400mg), L-carnitine fumarate (NOT ACETYL), b-complex preferably twice a day. Then while taking all of the above critical supplements and the rest of the necessary basics, a, e, c, calcium, titrating up to 4x 5mg mb12 per day and 4x 3mg adb12 per day.
Effectiveness of the active b12s and folate have been dependent on any or all of these critical cofactors being present for quite a few people and some require higher dosage levels for effectiveness.
Considering that the active b12s are a minimum of 100x more effective than hydroxyb12 this is a bit surprising. However, if all of the above specifics are satisfied then there is an additional possiblility. Because it is an injection and puts a much higher serum level into the blood for a short time the b12 can penetrate the cereberal spinal fluid by diffusion whereas a smaller dose or a normal sublingual dose would not. As studies have shown that CFS/FMS patients have a much lower CSF cobalamin level no matter what the body level is this can be the case. So therefore a 50mg single dose of mb12 and a 51mg single dose of adb12 each retained for a 2-3 hour period is the final test as the deficiency can be either one or both. As with the body test, any result, often an increase in energy or increase in clarity can be the result. If the basics and critical cofactors are not all being taken this test will be no more successful than the other trial of the more usual amounts as the critical cofactors really can be critical and the basics really are needed for tissue healing.
It might have helped if you had communicated along the way so that all these things could have been made sure of before now because from the way you say it I suspect that you have not followed the recipe which can be at least as critical as in baking a cake from scratch. Leave out the eggs or the flour or whatever in a cake and it doesn't work. Same here. So let's go over what you have been doing and make corrections and then try it, assuming you want it to work or at least to be sure that it really doesn't.
If you had some results from hydroxyb12 you ought to have much more from this except in the CSF case I explained above or unless that injection exhausted one or more cofactors, which can also occur. Let me know. Good luck.