I have been extremely sensitive to methylcobalamin and methylfolate for a long time. Even a grain of a tabulate would set into motion head pain, jittery, nervousness etc.
There are 3 general classes of MTHFR people
A) those who take those supplements without problem
B) those who take those supplements WITH problems but by starting small are able to gradually take them
C) those who are extremely sensitive to the supplement
This supplement may help group B and C with sensitivity
I came across a supplement called Lithium Orotate. It is one of the most powerful brain supplements I have come across.This supplement has allowed me to take cobalamin and methylfolate without the side effects.
Clinical research has found lithium active in the following functions:
Protecting brain cells from toxicity
Promoting brain cell regeneration
Increasing gray matter of the brain
Regulating brain neurotransmitters
Supporting healthy mood balance
Improving blood sugar metabolism
Here are some links about the benefits
READ THIS
http://tahomaclinic.com/2010/05/lithium-the-misunderstood-mineral-part-1/
http://tahomaclinic.com/2010/05/lithium-the-misunderstood-mineral-part-2/
Here is a FAQ link on it. It is the most complete information on the internet for the supplement I have found. Please read this fully.
IMPORTANT TO READ
http://www.thelithiumdoctor.com/faqs/
Please be aware that
5 mg of Lithium Orotate contains 0.2 ELEMENTAL Lithium.
120 mg of Lithium Orotate contains 4.6 ELEMENTAL Lithium.
The supposed toxic dose of Lithium is 100 mg of EL Lithium so one would have to take more than 25 120mg tablets to exceed that. That may apply to most people but not you. Funny thing is that the 5 mg capsule is way larger than the 120 mg tablet
EXCERPT START
The overall elimination half-life of lithium is approximately 24 hours.
Lithium is distributed slowly and unevenly in the human body. Distribution is usually complete within 12 hours of first ingestion. During lithium therapy, steady state concentrations are generally reached within 4-7 days of repeated oral application in patients with normal renal function.
What is the safe maximum serving of LO?
As a general rule for most of the adult and adolescent population the safe maximum serving of LO is 100mg/day of pure elemental lithium (EL). However there are exceptions to this rule. So to be on the safe side, if you intend to use LO in excess of 40mg of EL (for the long term), you should consult with your physician or call Dr. Millar for a consultation. Dr. Millar is also available to consult with your physician during your office visit with your doctor so both of you can collectively ask questions of Dr. Millar together.
The good news is that once your nervous system and endocrine (hormonal) glands have had time to heal and regenerate you will be able to drastically reduce your LO daily serving (maintenance serving).
You can start lowering your serving within 1 month of using LO. If you back slide into the same symptoms as before, then you are not ready to reduce your serving yet. Try reducing every 30 days until you are able to maintain the positive results you have achieved at a lower serving. This is a trial and error process and only you will know what the best serving is for you. A physician cannot tell you what is best for you regarding your lower maintenance serving.
EXCERPT END
I started out taking 5 mg just to see if I had any sensitivity to it. I felt a positive effect. I raised it to 10 mg next day. Still no problem. Next day I tried 20 mg for 3 or 4 days. Next I tried 60 mg. Still feeling positive effect. I went up to 120 mg without problem. I raised it to 240 mg but I felt sleepy so I dropped back down. I estimate that I could go to 150 mg without problems. I am staying at 120 mg for now. I will try to lower at to 60 mg sometime in future to see how low I can go. I have been taking this for around one month i think.
As far as taking the methylcobalamin, I did that slowly. I first started with hydroxycobalamin and after I worked my way gradually to higher doses of 2500 mcg then I did same thing with methylcobalamin to 2500 mcg. I am staying at 400-800 mcg of methylfolate for now. I will try playing with higher doses. Someone has analogized the methylcobalamin as wood and methylfolate as fire. Not sure if that is true but I want to be careful about it.
Please be aware that I also had to manage my occipital neuralgia and ATN with Taurine and Magtein before.
I have had many benefits.
1) I haven't needed to take Taurine and Magtein to quell glutamate anxiety.
2) I feel my neurotransmitters are more balanced whereas before there was more chaos
3) I haven't needed to take Magtein to avoid severe brain fog
4) I can take methylfolate and methylcobalmin without head pain, nervousness, jittery and anxiety
5) I believe it has moderated my high cortisol level
I came across Yasko who was finding that her MTHFR patients were deficient in Lithium.
The only anecdotal side effect I have read is mention of being possible adverse for hypothyroid and weight gain but those anecdotes didn't provide anything but vague info. Read that FAQ link above also. It's long but worth it.
I may have had hypothyroid problems before but resolved it with Conjugated Linoleic Acid. It is important to take it with saturated fat because research has said it won't work unless saturated fat is present.
I am surprised that more posts on this haven't popped up about this. I searched for years on this topic and hardly a peep.
Of course, I am not done commenting on this. I will try to give update within 12 months.
Hope this helps someone out there
There are 3 general classes of MTHFR people
A) those who take those supplements without problem
B) those who take those supplements WITH problems but by starting small are able to gradually take them
C) those who are extremely sensitive to the supplement
This supplement may help group B and C with sensitivity
I came across a supplement called Lithium Orotate. It is one of the most powerful brain supplements I have come across.This supplement has allowed me to take cobalamin and methylfolate without the side effects.
Clinical research has found lithium active in the following functions:
Protecting brain cells from toxicity
Promoting brain cell regeneration
Increasing gray matter of the brain
Regulating brain neurotransmitters
Supporting healthy mood balance
Improving blood sugar metabolism
Here are some links about the benefits
READ THIS
http://tahomaclinic.com/2010/05/lithium-the-misunderstood-mineral-part-1/
http://tahomaclinic.com/2010/05/lithium-the-misunderstood-mineral-part-2/
Here is a FAQ link on it. It is the most complete information on the internet for the supplement I have found. Please read this fully.
IMPORTANT TO READ
http://www.thelithiumdoctor.com/faqs/
Please be aware that
5 mg of Lithium Orotate contains 0.2 ELEMENTAL Lithium.
120 mg of Lithium Orotate contains 4.6 ELEMENTAL Lithium.
The supposed toxic dose of Lithium is 100 mg of EL Lithium so one would have to take more than 25 120mg tablets to exceed that. That may apply to most people but not you. Funny thing is that the 5 mg capsule is way larger than the 120 mg tablet
EXCERPT START
The overall elimination half-life of lithium is approximately 24 hours.
Lithium is distributed slowly and unevenly in the human body. Distribution is usually complete within 12 hours of first ingestion. During lithium therapy, steady state concentrations are generally reached within 4-7 days of repeated oral application in patients with normal renal function.
What is the safe maximum serving of LO?
As a general rule for most of the adult and adolescent population the safe maximum serving of LO is 100mg/day of pure elemental lithium (EL). However there are exceptions to this rule. So to be on the safe side, if you intend to use LO in excess of 40mg of EL (for the long term), you should consult with your physician or call Dr. Millar for a consultation. Dr. Millar is also available to consult with your physician during your office visit with your doctor so both of you can collectively ask questions of Dr. Millar together.
The good news is that once your nervous system and endocrine (hormonal) glands have had time to heal and regenerate you will be able to drastically reduce your LO daily serving (maintenance serving).
You can start lowering your serving within 1 month of using LO. If you back slide into the same symptoms as before, then you are not ready to reduce your serving yet. Try reducing every 30 days until you are able to maintain the positive results you have achieved at a lower serving. This is a trial and error process and only you will know what the best serving is for you. A physician cannot tell you what is best for you regarding your lower maintenance serving.
EXCERPT END
I started out taking 5 mg just to see if I had any sensitivity to it. I felt a positive effect. I raised it to 10 mg next day. Still no problem. Next day I tried 20 mg for 3 or 4 days. Next I tried 60 mg. Still feeling positive effect. I went up to 120 mg without problem. I raised it to 240 mg but I felt sleepy so I dropped back down. I estimate that I could go to 150 mg without problems. I am staying at 120 mg for now. I will try to lower at to 60 mg sometime in future to see how low I can go. I have been taking this for around one month i think.
As far as taking the methylcobalamin, I did that slowly. I first started with hydroxycobalamin and after I worked my way gradually to higher doses of 2500 mcg then I did same thing with methylcobalamin to 2500 mcg. I am staying at 400-800 mcg of methylfolate for now. I will try playing with higher doses. Someone has analogized the methylcobalamin as wood and methylfolate as fire. Not sure if that is true but I want to be careful about it.
Please be aware that I also had to manage my occipital neuralgia and ATN with Taurine and Magtein before.
I have had many benefits.
1) I haven't needed to take Taurine and Magtein to quell glutamate anxiety.
2) I feel my neurotransmitters are more balanced whereas before there was more chaos
3) I haven't needed to take Magtein to avoid severe brain fog
4) I can take methylfolate and methylcobalmin without head pain, nervousness, jittery and anxiety
5) I believe it has moderated my high cortisol level
I came across Yasko who was finding that her MTHFR patients were deficient in Lithium.
The only anecdotal side effect I have read is mention of being possible adverse for hypothyroid and weight gain but those anecdotes didn't provide anything but vague info. Read that FAQ link above also. It's long but worth it.
I may have had hypothyroid problems before but resolved it with Conjugated Linoleic Acid. It is important to take it with saturated fat because research has said it won't work unless saturated fat is present.
I am surprised that more posts on this haven't popped up about this. I searched for years on this topic and hardly a peep.
Of course, I am not done commenting on this. I will try to give update within 12 months.
Hope this helps someone out there
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